Exploration and understanding of endocrine mono- and combination therapy resistance in hormone receptor positive/HER2 negative breast cancer

Zhangzan Huang

Exploration and understanding of endocrine mono- and combination therapy resistance in hormone receptor positive/HER2 negative breast cancer

Zhangzan Huang

Medical Oncology

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

In this thesis, we extended the investigation of endocrine therapy resistance in HR+/HER2- breast cancer, aiming to elucidate cross-resistance mechanisms and identify potential response biomarkers. The research in this thesis is structured as follows, from functional and discovery research in cellular model systems to translational research in clinical specimen.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Martens, John, Supervisor Jansen, Maurice P.H.M., Co-supervisor
Award date	23 Apr 2026
Place of Publication	Rotterdam
Print ISBNs	978-90-9042-124-7
Publication status	Published - 23 Apr 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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final dissertation Huang, ZhangzanFinal published version, 8.96 MB

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title = "Exploration and understanding of endocrine mono- and combination therapy resistance in hormone receptor positive/HER2 negative breast cancer",

abstract = "In this thesis, we extended the investigation of endocrine therapy resistance in HR+/HER2- breast cancer, aiming to elucidate cross-resistance mechanisms and identify potential response biomarkers. The research in this thesis is structured as follows, from functional and discovery research in cellular model systems to translational research in clinical specimen.",

author = "Zhangzan Huang",

year = "2026",

month = apr,

day = "23",

language = "English",

isbn = "978-90-9042-124-7",

school = "Erasmus University Rotterdam",

}

TY - BOOK

T1 - Exploration and understanding of endocrine mono- and combination therapy resistance in hormone receptor positive/HER2 negative breast cancer

AU - Huang, Zhangzan

PY - 2026/4/23

Y1 - 2026/4/23

N2 - In this thesis, we extended the investigation of endocrine therapy resistance in HR+/HER2- breast cancer, aiming to elucidate cross-resistance mechanisms and identify potential response biomarkers. The research in this thesis is structured as follows, from functional and discovery research in cellular model systems to translational research in clinical specimen.

AB - In this thesis, we extended the investigation of endocrine therapy resistance in HR+/HER2- breast cancer, aiming to elucidate cross-resistance mechanisms and identify potential response biomarkers. The research in this thesis is structured as follows, from functional and discovery research in cellular model systems to translational research in clinical specimen.

M3 - Doctoral Thesis

SN - 978-90-9042-124-7

CY - Rotterdam

ER -

Exploration and understanding of endocrine mono- and combination therapy resistance in hormone receptor positive/HER2 negative breast cancer

Abstract

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