Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population

J. M. Poos, E. van den Berg, E. Visch-Brink, W. S. Eikelboom, S. Franzen, J. van Hemmen, Y. A. L. Pijnenburg, D. Satoer, E. G. P. Dopper, J. C. van Swieten, J. M. Papma, H. Seelaar, L. C. Jiskoot*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective: To investigate the differential ability of the "Test Relaties Abstracte Concepten"(TRACE), a Dutch test for abstract semantic knowledge, in frontotemporal dementia (FTD). Methods: The TRACE was administered in patients with behavioral variant FTD (bvFTD; n = 16), nonfluent variant (nfvPPA; n = 10), logopenic variant (lvPPA; n = 10), and semantic variant primary progressive aphasia (svPPA; n = 9), and controls (n = 59). We examined group differences, performed correlational analyses with other neuropsychological tests and investigated discriminative ability. We compared the TRACE with a semantic association test for concrete stimuli (SAT). Results: All patient groups, except nfvPPA, performed worse on the TRACE than controls (p <. 01). svPPA patients performed worse than the other patient groups (p <. 05). The TRACE discriminated well between patient groups, except nfvPPA, versus controls (all p <. 01) and between svPPA versus other patient groups with high sensitivity (75-100%) and specificity (86%-92%). In bvFTD and nfvPPA the TRACE correlated with language tests (ρ > 0.6), whereas in svPPA the concrete task correlated (ρ ≥ 0.75) with language tests. Patients with bvFTD, nfvPPA and lvPPA performed lower on the TRACE than the SAT (p <. 05), whereas patients with svPPA were equally impaired on both tasks (p =. 2). Discussion: We demonstrated impaired abstract semantic knowledge in patients with bvFTD, lvPPA, and svPPA, but not nfvPPA, with svPPA patients performing worse than the other subtypes. The TRACE was a good classifier between each patient group versus controls and between svPPA versus other patient groups. This highlights the value of incorporating semantic tests with abstract stimuli into standard neuropsychological assessment for early differential diagnosis of FTD subtypes.

Original languageEnglish
Pages (from-to)104-116
Number of pages13
JournalArchives of Clinical Neuropsychology
Issue number1
Publication statusPublished - 1 Feb 2022

Bibliographical note

The FTD-RisC study is supported by Dioraphte Foundation [grant 09-02-00], the Association for Frontotemporal Dementias
Research Grant 2009, The Netherlands organization for Scientific Research (NWO) [grant HCMI 056-13-018]; ZonMw
Memorabel [project number 733 050 103 and 733 050 813]; JPND PreFrontAls consortium [project number 733051042];
Alzheimer Nederland and the Bluefield project.

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved.


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