Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer

Lotte Bakkerus, Beatriz Subtil, Hetty J. Bontkes, Elske C. Gootjes, Martine Reijm, Manon Vullings, Kiek Verrijp, John Melle Bokhorst, Carmen Woortman, Iris D. Nagtegaal, Marianne A. Jonker, Hans J. van der Vliet, Cornelis Verhoef, Mark A.J. Gorris, I. Jolanda M. de Vries, Tanja D. de Gruijl, Henk M.W. Verheul, Tineke E. Buffart, Daniele V.F. Tauriello*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently needed. The role of cancer immunity in metastatic CRC (mCRC) is poorly understood. Here, we explore cellular immune cell status in patients with multi-organ mCRC. We analyzed T cell infiltration in primary tumor sections, surveyed the lymphocytic landscape of liver metastases, and assessed circulating mononuclear immune cells. Besides asking whether immune cells are associated with survival at this stage of the disease, we investigated correlations between the different tissue types; as this could indicate a dominant immune phenotype. Taken together, our analyses corroborate previous observations that higher levels of CD8+ T lymphocytes link to better survival outcomes. Our findings therefore extend evidence from earlier stages of CRC to indicate an important role for cancer immunity in disease control even after metastatic spreading to multiple organs. This finding may help to improve predicting outcome of patients with mCRC and suggests a future role for immunotherapeutic strategies.

Original languageEnglish
Article number2361971
JournalOncoImmunology
Volume13
Issue number1
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

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