TY - JOUR
T1 - Exploring the Effectiveness of Self-Management Interventions in Type 2 Diabetes
T2 - A Systematic Review and Network Meta-Analysis
AU - Tsokani, Sofia
AU - Seitidis, Georgios
AU - Christogiannis, Christos
AU - Kontouli, Katerina Maria
AU - Nikolakopoulos, Stavros
AU - Zevgiti, Stella
AU - Orrego, Carola
AU - Ballester, Marta
AU - Suñol, Rosa
AU - Heijmans, Monique
AU - Poortvliet, Rune
AU - van der Gaag, Marieke
AU - Alonso-Coello, Pablo
AU - Canelo-Aybar, Carlos
AU - Beltran, Jessica
AU - González-González, Ana I.
AU - de Graaf, Gimon
AU - Veroniki, Areti Angeliki
AU - Mavridis, Dimitrios
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12/22
Y1 - 2023/12/22
N2 - Background: Chronic diseases are a leading cause of global morbidity and mortality. In response to this challenge, self-management interventions (SMIs) have emerged as an essential tool in improving patient outcomes. However, the diverse and complex nature of SMIs pose significant challenges in measuring their effectiveness. This work aims to investigate the comparative effectiveness of SMIs on Type 2 diabetes mellitus (T2DM) outcomes. Methods: A rigorous analytical framework was employed to assess the relative effectiveness of different SMIs, encompassing both pairwise and network meta-analysis (NMA), as well as component network meta-analysis (CNMA). Various outcomes were considered, including glycated hemoglobin (HbA1c) control, body mass index (BMI) reduction and low-density lipoprotein (LDL) cholesterol. Visualization tools were also utilized to enhance the interpretation of results. Results: SMIs were found promising in improving clinical outcomes and patient-reported measures. However, considerable heterogeneity and inconsistency across studies challenged the validity of NMA results. CNMA along with various visualization tools offered insights into the contributions of individual SMI components, highlighting the complexity of these interventions. Discussion/Conclusions: SMIs represent a valuable approach to managing chronic conditions, but their effectiveness is context-dependent. Further research is needed to elucidate the contextual factors influencing SMI outcomes. This work contributes to a comprehensive understanding of SMIs’ role in T2DM management, aiming to aid decision-makers, clinicians, and patients in selecting tailored interventions.
AB - Background: Chronic diseases are a leading cause of global morbidity and mortality. In response to this challenge, self-management interventions (SMIs) have emerged as an essential tool in improving patient outcomes. However, the diverse and complex nature of SMIs pose significant challenges in measuring their effectiveness. This work aims to investigate the comparative effectiveness of SMIs on Type 2 diabetes mellitus (T2DM) outcomes. Methods: A rigorous analytical framework was employed to assess the relative effectiveness of different SMIs, encompassing both pairwise and network meta-analysis (NMA), as well as component network meta-analysis (CNMA). Various outcomes were considered, including glycated hemoglobin (HbA1c) control, body mass index (BMI) reduction and low-density lipoprotein (LDL) cholesterol. Visualization tools were also utilized to enhance the interpretation of results. Results: SMIs were found promising in improving clinical outcomes and patient-reported measures. However, considerable heterogeneity and inconsistency across studies challenged the validity of NMA results. CNMA along with various visualization tools offered insights into the contributions of individual SMI components, highlighting the complexity of these interventions. Discussion/Conclusions: SMIs represent a valuable approach to managing chronic conditions, but their effectiveness is context-dependent. Further research is needed to elucidate the contextual factors influencing SMI outcomes. This work contributes to a comprehensive understanding of SMIs’ role in T2DM management, aiming to aid decision-makers, clinicians, and patients in selecting tailored interventions.
UR - http://www.scopus.com/inward/record.url?scp=85181871463&partnerID=8YFLogxK
U2 - 10.3390/healthcare12010027
DO - 10.3390/healthcare12010027
M3 - Review article
C2 - 38200933
AN - SCOPUS:85181871463
SN - 2227-9032
VL - 12
JO - Healthcare (Switzerland)
JF - Healthcare (Switzerland)
IS - 1
M1 - 27
ER -
