Exposure to cyan or red light inhibits the axial growth of zebrafish eyes

Wim H. Quint, Renee van Buuren, Nina C.C.J. Kokke, Magda A. Meester-Smoor, Rob Willemsen, Rémy Broersma, Adriana I. Iglesias, Marcel Lucassen, Caroline C.W. Klaver*

*Corresponding author for this work

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Myopia, or nearsightedness, is the most common type of refractive error and is characterized by a mismatch between the optical power and ocular axial length. Light, and more specifically the spectral composition of light, has been known to influence myopic axial growth. In this pilot study, we exposed zebrafish to illuminations that vary in spectral composition and screened for changes in axial length. The illumination spectra included narrow band ultra-violet A (UVA) (peak wavelength 369 nm), violet (425 nm), cyan (483 nm), green/yellow (557 nm), and red (633 nm) light, as well as broad band white light (2700 K and 6500 K), dim white light and broad spectrum (day) light. We found that rearing zebrafish in cyan or red light leads to a reduction of the ocular axial length. The results of this pilot study may contribute to new perspectives on the role of light and lighting as an intervention strategy for myopia control.

Original languageEnglish
Article number109437
JournalExperimental Eye Research
Publication statusPublished - May 2023

Bibliographical note

Funding Information:
Funding for this work was supported by the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (grant 648268 ) and the Netherlands Organisation for Scientific Research (NWO, grant 91815655 and VidW. 1154.18.046 ), UitZicht (project 2018–29 ), Prof Dr. Henkes Stichting.

Publisher Copyright:
© 2023 The Authors


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