Expression of PDGF chains and PDGF receptors in human malignant and normal mesothelial cell lines

M. A. Versnel*, A. W. Langerak, T. H. Van Der Kwast, H. C. Hoogsteden, A. Hagemeijer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

A panel of human malignant mesothelioma cell lines and normal mesothelial cells was investigated for the expression of the genes coding for the platelet-derived growth factor (PDGF) A-chain, PDGF B-chain, PDGF α-receptor and PDGF β-receptor. The human malignant mesothelioma cell lines were found to express the PDGF A-chain, PDGF B-chain and PDGF β-receptor. Normal mesothelial cell lines were found to express the PDGF A-chain at a low level and the PDGF α-receptor. The PDGF β-receptor expression in normal mesothelial cells is generally weak to undetectable and sometimes stronger. The coexpression of PDGF B-chains and PDGF β-receptors on human malignant mesothelioma cell lines and the absence of PDGF B-chain expression in normal mesothelial cells suggests that the homo dimeric PDGF-BB protein can function as an autocrine growth factor and play a role in the stimulation of the growth of the tumour cells. In cultured normal mesothelial cells, on the other hand, PDGF-AA acting via the PDGF α-receptor may be involved in autocrine growth stimulation.

Original languageEnglish
Pages (from-to)186-188
Number of pages3
JournalEuropean Respiratory Review
Volume3
Issue number11
Publication statusPublished - 1993

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