External basic hyperthermia devices for preclinical studies in small animals

Marjolein I. Priester, Sergio Curto, Gerard C. van Rhoon, Timo L.M. Ten Hagen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

17 Citations (Scopus)
95 Downloads (Pure)


Preclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Reproducibility of methods in and between research groups on the same techniques is crucial to have a better prediction of the clinical outcome and to improve new treatment strategies (for instance with heat‐sensitive nanoparticles). Here we provide a preclinically oriented review on the use and applicability of basic hyperthermia systems available for solid tumor thermal treatment in small animals. The complexity of these techniques ranges from a simple, low‐cost water bath approach, irradiation with light or lasers, to advanced ultrasound and capacitive heating devices.

Original languageEnglish
Article number4628
Issue number18
Publication statusPublished - 15 Sept 2021

Bibliographical note

Funding Information:
Funding: This research was supported by the MRace Grant 2017–21. In addition, this project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie grant agreement No. 845645.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


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