Farmacotherapie bij sociale fobie, gegeneraliseerde angststoornis en separatieangststoornis bij kinderen en adolescenten: Een literatuuroverzicht

Translated title of the contribution: Pharmacotherapy for social phobia, generalised anxiety disorder and separation anxiety disorder in children and adolescents: An overview

G. C. Dieleman*, R. F. Ferdinand

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

10 Citations (Scopus)

Abstract

BACKGROUND: Anxiety disorders are among the most prevalent psychiatric disorders during childhood. They are often persistent and are associated with a number of negative outcomes. Therefore, effective treatment is required. AIM: To present an overview of placebo-controlled studies of pharmacotherapy for social phobia, generalised anxiety disorder and separation anxiety disorder in children an adolescents and to determine which medication is the most effective.

METHOD: The literature was reviewed using Pubmed.

RESULTS: Nine randomised double-blind studies on the efficacy of pharmacotherapy for generalised anxiety disorder, separation anxiety disorder and social phobia were found. Tricyclic antidepressants were not more effective than placebo. Studies on benzodiazepines showed that the effect of these drugs was not superior to that of placebo either. Studies of the efficacy of SSRIS, however, proved that they were superior to placebo.

CONCLUSION: SSRIS are the drugs of first choice for the treatment of social phobias, separation anxiety disorder and generalised anxiety disorder in children and adolescents. There is strong evidence that SSRIS are effective for the treatment of these anxiety disorders; the standardised effect size varies between medium and large.

Translated title of the contributionPharmacotherapy for social phobia, generalised anxiety disorder and separation anxiety disorder in children and adolescents: An overview
Original languageDutch
Pages (from-to)43-53
Number of pages11
JournalTijdschrift voor Psychiatrie
Volume50
Issue number1
Publication statusPublished - 9 Jan 2008

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