FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to Y-secretase inhibitors

J O'Neil; J Grimm; P Strack; S Rao; D Tibbitts; C Winter; J Hardwick; M Welcker; Jules Meijerink; Rob Pieters; G Draetta; R Sears; BE Clurman; AT Look

doi:10.1084/jem.20070876

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to Y-secretase inhibitors

J O'Neil, J Grimm, P Strack, S Rao, D Tibbitts, C Winter, J Hardwick, M Welcker, Jules Meijerink, Rob Pieters, G Draetta, R Sears, BE Clurman, AT Look

Pediatrics

Research output: Contribution to journal › Article › Academic › peer-review

584 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	1813-1824
Number of pages	12
Journal	Journal of Experimental Medicine
Volume	204
Issue number	8
DOIs	https://doi.org/10.1084/jem.20070876
Publication status	Published - 2007

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EMC MM-02-54-03

Access to Document

10.1084/jem.20070876

http://hdl.handle.net/1765/35257

Cite this

O'Neil, J., Grimm, J., Strack, P., Rao, S., Tibbitts, D., Winter, C., Hardwick, J., Welcker, M., Meijerink, J., Pieters, R., Draetta, G., Sears, R., Clurman, BE., & Look, AT. (2007). FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to Y-secretase inhibitors. Journal of Experimental Medicine, 204(8), 1813-1824. https://doi.org/10.1084/jem.20070876

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O'Neil, J, Grimm, J, Strack, P, Rao, S, Tibbitts, D, Winter, C, Hardwick, J, Welcker, M, Meijerink, J, Pieters, R, Draetta, G, Sears, R, Clurman, BE & Look, AT 2007, 'FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to Y-secretase inhibitors', Journal of Experimental Medicine, vol. 204, no. 8, pp. 1813-1824. https://doi.org/10.1084/jem.20070876

TY - JOUR

T1 - FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to Y-secretase inhibitors

AU - O'Neil, J

AU - Grimm, J

AU - Strack, P

AU - Rao, S

AU - Tibbitts, D

AU - Winter, C

AU - Hardwick, J

AU - Welcker, M

AU - Meijerink, Jules

AU - Pieters, Rob

AU - Draetta, G

AU - Sears, R

AU - Clurman, BE

AU - Look, AT

PY - 2007

Y1 - 2007

U2 - 10.1084/jem.20070876

DO - 10.1084/jem.20070876

M3 - Article

C2 - 17646409

SN - 0022-1007

VL - 204

SP - 1813

EP - 1824

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 8

ER -