TY - JOUR
T1 - Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma
AU - Sawada, T
AU - Shite, J
AU - Garcia Garcia, Hector
AU - Shinke, T
AU - Watanabe, S
AU - Otake, H
AU - Matsumoto, D
AU - Tanino, Y
AU - Ogasawara, D
AU - Kawamori, H
AU - Kato, H
AU - Miyoshi, N
AU - Yokoyama, M
AU - Serruys, PWJC (Patrick)
AU - Hirata, K
PY - 2008
Y1 - 2008
N2 - Aims To evaluate the feasibility of the combined use of virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). Methods and results In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS and OCT. IVUS-derived TCFA was defined as an abundant necrotic core (> 10% of the cross-sectional area) in contact with the lumen (NCCL) and %plaque-volume > 40%. OCT-derived TCFA was defined as a fibrous cap thickness of < 65 mu m overlying a low-intensity area with an unclear border. Plaque meeting both TCFA criteria was defined as definite-TCFA. Sixty-one plaques were diagnosed as IVUS-derived TCFA and 36 plaques as OCT-derived TCFA. Twenty-eight plaques were diagnosed as definite-TCFA; the remaining 33 IVUS-derived TCFA had a non-thin-cap and eight OCT-derived TCFA had a non-NCCL (in discord with NCCL visualized by VH-IVUS, mainly due to misreading caused by dense calcium). Based on IVUS findings, definite-TCFA showed a larger plaque and vessel volume, %plaque-volume, higher vessel remodelling index, and greater angle occupied by the NCCL in the lumen circumference than non-thin-cap IVUS-derived TCFA. Conclusion Neither modality alone is sufficient for detecting TCFA. The combined use of OCT and VH-IVUS might be a feasible approach for evaluating TCFA.
AB - Aims To evaluate the feasibility of the combined use of virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). Methods and results In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS and OCT. IVUS-derived TCFA was defined as an abundant necrotic core (> 10% of the cross-sectional area) in contact with the lumen (NCCL) and %plaque-volume > 40%. OCT-derived TCFA was defined as a fibrous cap thickness of < 65 mu m overlying a low-intensity area with an unclear border. Plaque meeting both TCFA criteria was defined as definite-TCFA. Sixty-one plaques were diagnosed as IVUS-derived TCFA and 36 plaques as OCT-derived TCFA. Twenty-eight plaques were diagnosed as definite-TCFA; the remaining 33 IVUS-derived TCFA had a non-thin-cap and eight OCT-derived TCFA had a non-NCCL (in discord with NCCL visualized by VH-IVUS, mainly due to misreading caused by dense calcium). Based on IVUS findings, definite-TCFA showed a larger plaque and vessel volume, %plaque-volume, higher vessel remodelling index, and greater angle occupied by the NCCL in the lumen circumference than non-thin-cap IVUS-derived TCFA. Conclusion Neither modality alone is sufficient for detecting TCFA. The combined use of OCT and VH-IVUS might be a feasible approach for evaluating TCFA.
U2 - 10.1093/eurheartj/ehn132
DO - 10.1093/eurheartj/ehn132
M3 - Article
SN - 0195-668X
VL - 29
SP - 1136
EP - 1146
JO - European Heart Journal
JF - European Heart Journal
IS - 9
ER -