Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population

Sophia M. Blaauwendraad; Danielle R. Stevens; Michiel A. van den Dries; Romy Gaillard; Anjoeka Pronk; Suzanne Spaan; Kelly K. Ferguson; Vincent W.V. Jaddoe

doi:10.1289/EHP12267

Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population

Sophia M. Blaauwendraad, Danielle R. Stevens, Michiel A. van den Dries, Romy Gaillard, Anjoeka Pronk, Suzanne Spaan, Kelly K. Ferguson, Vincent W.V. Jaddoe^*

^*Corresponding author for this work

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Abstract

BACKGROUND: Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE: We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. METHODS: Between 2002 and 2006, we included 642 mother–child pairs from the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. We measured maternal urinary concentrations of OP pesticide metabolites, namely, dialkyl phosphates, including three dimethyl and three diethyl phosphates in early-, mid-and late-pregnancy. At 10 years of age, child total and regional body fat and lean mass were measured through dual energy X-ray absorptiometry, and abdominal and organ fat through magnetic resonance imaging. RESULTS: Higher maternal urinary pregnancy-average or trimester-specific dialkyl, dimethyl, or diethyl phosphate concentrations were not associated with childhood BMI and the risk of overweight. In addition, we did not observe any association of dialkyl, dimethyl, or diethyl phosphate concentrations with total and regional body fat, abdominal visceral fat, liver fat, or pericardial fat at child age of 10 y. CONCLUSION: We observed no associations of maternal urinary dialkyl concentrations during pregnancy with childhood adiposity measures at 10 years of age. Whether these associations develop at older ages should be further studied.

Original language	English
Article number	087014
Journal	Environmental Health Perspectives
Volume	131
Issue number	8
DOIs	https://doi.org/10.1289/EHP12267
Publication status	Published - 22 Aug 2023

Bibliographical note

Funding Information:
The Generation R Study is financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, and the Netherlands Organization for Health Research and Development.

Funding Information:
V.W.V.J. received a grant from the Netherlands Organization for Health Research and Development (NWO; ZonMw-VIDI 016.136.361) and a European Research Council Consolidator Grant (ERC-2014-CoG-648916). R.G. received funding from the Dutch Heart Foundation (2017T013), the Dutch Diabetes Foundation (2017.81.002), and the Netherlands Organization for Health Research and Development (ZonMW; 543003109). This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the ERA-NET Cofund action (no. 727565), European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, EndObesity). In addition, this work was supported by the European Union’s Horizon 2020 Research and Innovation agreement 874583 (ATHLETE Project).

Publisher Copyright:
© 2023, Public Health Services, US Dept of Health and Human Services. All rights reserved.

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title = "Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population",

abstract = "BACKGROUND: Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE: We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. METHODS: Between 2002 and 2006, we included 642 mother–child pairs from the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. We measured maternal urinary concentrations of OP pesticide metabolites, namely, dialkyl phosphates, including three dimethyl and three diethyl phosphates in early-, mid-and late-pregnancy. At 10 years of age, child total and regional body fat and lean mass were measured through dual energy X-ray absorptiometry, and abdominal and organ fat through magnetic resonance imaging. RESULTS: Higher maternal urinary pregnancy-average or trimester-specific dialkyl, dimethyl, or diethyl phosphate concentrations were not associated with childhood BMI and the risk of overweight. In addition, we did not observe any association of dialkyl, dimethyl, or diethyl phosphate concentrations with total and regional body fat, abdominal visceral fat, liver fat, or pericardial fat at child age of 10 y. CONCLUSION: We observed no associations of maternal urinary dialkyl concentrations during pregnancy with childhood adiposity measures at 10 years of age. Whether these associations develop at older ages should be further studied.",

author = "Blaauwendraad, {Sophia M.} and Stevens, {Danielle R.} and {van den Dries}, {Michiel A.} and Romy Gaillard and Anjoeka Pronk and Suzanne Spaan and Ferguson, {Kelly K.} and Jaddoe, {Vincent W.V.}",

note = "Funding Information: The Generation R Study is financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, and the Netherlands Organization for Health Research and Development. Funding Information: V.W.V.J. received a grant from the Netherlands Organization for Health Research and Development (NWO; ZonMw-VIDI 016.136.361) and a European Research Council Consolidator Grant (ERC-2014-CoG-648916). R.G. received funding from the Dutch Heart Foundation (2017T013), the Dutch Diabetes Foundation (2017.81.002), and the Netherlands Organization for Health Research and Development (ZonMW; 543003109). This project has received funding from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme under the ERA-NET Cofund action (no. 727565), European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, EndObesity). In addition, this work was supported by the European Union{\textquoteright}s Horizon 2020 Research and Innovation agreement 874583 (ATHLETE Project). Publisher Copyright: {\textcopyright} 2023, Public Health Services, US Dept of Health and Human Services. All rights reserved.",

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AU - Blaauwendraad, Sophia M.

AU - Stevens, Danielle R.

AU - van den Dries, Michiel A.

AU - Gaillard, Romy

AU - Pronk, Anjoeka

AU - Spaan, Suzanne

AU - Ferguson, Kelly K.

AU - Jaddoe, Vincent W.V.

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PY - 2023/8/22

Y1 - 2023/8/22

N2 - BACKGROUND: Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE: We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. METHODS: Between 2002 and 2006, we included 642 mother–child pairs from the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. We measured maternal urinary concentrations of OP pesticide metabolites, namely, dialkyl phosphates, including three dimethyl and three diethyl phosphates in early-, mid-and late-pregnancy. At 10 years of age, child total and regional body fat and lean mass were measured through dual energy X-ray absorptiometry, and abdominal and organ fat through magnetic resonance imaging. RESULTS: Higher maternal urinary pregnancy-average or trimester-specific dialkyl, dimethyl, or diethyl phosphate concentrations were not associated with childhood BMI and the risk of overweight. In addition, we did not observe any association of dialkyl, dimethyl, or diethyl phosphate concentrations with total and regional body fat, abdominal visceral fat, liver fat, or pericardial fat at child age of 10 y. CONCLUSION: We observed no associations of maternal urinary dialkyl concentrations during pregnancy with childhood adiposity measures at 10 years of age. Whether these associations develop at older ages should be further studied.

AB - BACKGROUND: Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE: We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. METHODS: Between 2002 and 2006, we included 642 mother–child pairs from the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. We measured maternal urinary concentrations of OP pesticide metabolites, namely, dialkyl phosphates, including three dimethyl and three diethyl phosphates in early-, mid-and late-pregnancy. At 10 years of age, child total and regional body fat and lean mass were measured through dual energy X-ray absorptiometry, and abdominal and organ fat through magnetic resonance imaging. RESULTS: Higher maternal urinary pregnancy-average or trimester-specific dialkyl, dimethyl, or diethyl phosphate concentrations were not associated with childhood BMI and the risk of overweight. In addition, we did not observe any association of dialkyl, dimethyl, or diethyl phosphate concentrations with total and regional body fat, abdominal visceral fat, liver fat, or pericardial fat at child age of 10 y. CONCLUSION: We observed no associations of maternal urinary dialkyl concentrations during pregnancy with childhood adiposity measures at 10 years of age. Whether these associations develop at older ages should be further studied.

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Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population

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