TY - JOUR
T1 - Fetal Speckle Tracking Echocardiography Measured Global Longitudinal Strain and Strain Rate in Congenital Heart Disease
T2 - A Systematic Review and Meta-Analysis
AU - van den Wildenberg, Sarah
AU - van Beynum, Ingrid M.
AU - Havermans, Malou E.C.
AU - Boersma, Eric
AU - DeVore, Greggory R.
AU - Simpson, John M.
AU - Steegers, Eric A.P.
AU - Go, Attie T.J.I.
AU - Cornette, Jérôme M.J.
N1 - Publisher Copyright:
© 2024 The Author(s). Prenatal Diagnosis published by John Wiley & Sons Ltd.
PY - 2024/11
Y1 - 2024/11
N2 - Fetal two-dimensional speckle tracking echocardiography (2D-STE) is a novel technique that provides information on fetal heart function by measuring global longitudinal strain (GLS) and global longitudinal strain rate (GLSR). These features assess the longitudinal deformity of the fetal cardiac wall. 2D-STE is shown to be of prognostic value in children and adults with congenital heart disease (CHD). Therefore, its importance in fetal life should also be considered. This systematic review and meta-analysis provides an overview of the literature on 2D-STE (GLS/GLSR) in fetuses with CHD, focusing on the left and right ventricles (LV/RV). Findings indicated that LV-GLS was significantly lower in fetuses with coarctation of the aorta (CoA) and Tetralogy of Fallot (ToF) compared to controls. Conversely, fetuses with a single left ventricle exhibited higher LV-GLS. RV-GLS was significantly lower in fetuses with hypoplastic left heart syndrome (HLHS) and ToF compared to controls. LV-GLSR was significantly lower in fetuses with CoA. Overall, considerable heterogeneity was observed, possibly due to differences in study design. More prospective longitudinal studies on 2D-STE in fetuses with CHD, considering heterogeneity parameters, could offer better insights into this promising technique.
AB - Fetal two-dimensional speckle tracking echocardiography (2D-STE) is a novel technique that provides information on fetal heart function by measuring global longitudinal strain (GLS) and global longitudinal strain rate (GLSR). These features assess the longitudinal deformity of the fetal cardiac wall. 2D-STE is shown to be of prognostic value in children and adults with congenital heart disease (CHD). Therefore, its importance in fetal life should also be considered. This systematic review and meta-analysis provides an overview of the literature on 2D-STE (GLS/GLSR) in fetuses with CHD, focusing on the left and right ventricles (LV/RV). Findings indicated that LV-GLS was significantly lower in fetuses with coarctation of the aorta (CoA) and Tetralogy of Fallot (ToF) compared to controls. Conversely, fetuses with a single left ventricle exhibited higher LV-GLS. RV-GLS was significantly lower in fetuses with hypoplastic left heart syndrome (HLHS) and ToF compared to controls. LV-GLSR was significantly lower in fetuses with CoA. Overall, considerable heterogeneity was observed, possibly due to differences in study design. More prospective longitudinal studies on 2D-STE in fetuses with CHD, considering heterogeneity parameters, could offer better insights into this promising technique.
UR - http://www.scopus.com/inward/record.url?scp=85205728718&partnerID=8YFLogxK
U2 - 10.1002/pd.6672
DO - 10.1002/pd.6672
M3 - Review article
C2 - 39367541
AN - SCOPUS:85205728718
SN - 0197-3851
VL - 44
SP - 1479
EP - 1497
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 12
ER -