Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

Lesego M. Ramocha; Bernadette G. van den Hoogen; Vicky Baillie; Stefan van Nieuwkoop; Clare L. Cutland; Stephanie Jones; Andrew Moultrie; Alane Izu; Charl Verwey; Shabir A. Madhi; Jeffrey R. Dorfman

doi:10.1093/jpids/piac018

Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

Lesego M. Ramocha, Bernadette G. van den Hoogen, Vicky Baillie, Stefan van Nieuwkoop, Clare L. Cutland, Stephanie Jones, Andrew Moultrie, Alane Izu, Charl Verwey, Shabir A. Madhi, Jeffrey R. Dorfman

Virology

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	11
Issue number	7
DOIs	https://doi.org/10.1093/jpids/piac018
Publication status	Published - 1 Jul 2022

Bibliographical note

Funding Information:
This work was partially supported by the South African Research Chairs Initiative of the Department of Science and Innovation/National Research Foundation, the South African Medical Research Council, and the National Research Foundation of South Africa

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.

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10.1093/jpids/piac018

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Ramocha, L. M., van den Hoogen, B. G., Baillie, V., van Nieuwkoop, S., Cutland, C. L., Jones, S., Moultrie, A., Izu, A., Verwey, C., Madhi, S. A., & Dorfman, J. R. (2022). Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1. Journal of the Pediatric Infectious Diseases Society, 11(7), 341-344. https://doi.org/10.1093/jpids/piac018

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title = "Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1",

abstract = "Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.",

author = "Ramocha, \{Lesego M.\} and \{van den Hoogen\}, \{Bernadette G.\} and Vicky Baillie and \{van Nieuwkoop\}, Stefan and Cutland, \{Clare L.\} and Stephanie Jones and Andrew Moultrie and Alane Izu and Charl Verwey and Madhi, \{Shabir A.\} and Dorfman, \{Jeffrey R.\}",

note = "Funding Information: This work was partially supported by the South African Research Chairs Initiative of the Department of Science and Innovation/National Research Foundation, the South African Medical Research Council, and the National Research Foundation of South Africa Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.",

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doi = "10.1093/jpids/piac018",

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Ramocha, LM, van den Hoogen, BG, Baillie, V, van Nieuwkoop, S, Cutland, CL, Jones, S, Moultrie, A, Izu, A, Verwey, C, Madhi, SA & Dorfman, JR 2022, 'Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1', Journal of the Pediatric Infectious Diseases Society, vol. 11, no. 7, pp. 341-344. https://doi.org/10.1093/jpids/piac018

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T1 - Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

AU - Ramocha, Lesego M.

AU - van den Hoogen, Bernadette G.

AU - Baillie, Vicky

AU - van Nieuwkoop, Stefan

AU - Cutland, Clare L.

AU - Jones, Stephanie

AU - Moultrie, Andrew

AU - Izu, Alane

AU - Verwey, Charl

AU - Madhi, Shabir A.

AU - Dorfman, Jeffrey R.

N1 - Funding Information: This work was partially supported by the South African Research Chairs Initiative of the Department of Science and Innovation/National Research Foundation, the South African Medical Research Council, and the National Research Foundation of South Africa Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.

AB - Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.

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U2 - 10.1093/jpids/piac018

DO - 10.1093/jpids/piac018

M3 - Article

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AN - SCOPUS:85134855331

SN - 2048-7193

VL - 11

SP - 341

EP - 344

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 7

ER -

Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

Abstract

Bibliographical note

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