Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery?

E. Joanne Verweij, Martine C. de Vries, Esther J. Oldekamp, Alex J. Eggink, Dick Oepkes, Femke Slaghekke, Jochem K.H. Spoor, Jan A. Deprest, Jena L. Miller, Ahmet A. Baschat, Philip L.J. DeKoninck*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)

Abstract

Since the completion of the Management of Myelomeningocoele Study, maternal-fetal surgery for spina bifida has become a valid option for expecting parents. More recently, multiple groups are exploring a minimally invasive approach and recent outcomes have addressed many of the initial concerns with this approach. Based on a previously published framework, we attempt to delineate the developmental stage of the surgical techniques. Furthermore, we discuss the barriers of performing randomized controlled trials comparing two surgical interventions and suggest that data collection through registries is an alternative method to gather high-grade evidence.

Original languageEnglish
Pages (from-to)949-956
Number of pages8
JournalPrenatal Diagnosis
Volume41
Issue number8
DOIs
Publication statusPublished - 1 Jul 2021

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