Fibre optic intravascular measurements of blood flow: A review

Eleanor C. Mackle; Joanna M. Coote; Elizabeth Carr; Callum D. Little; Gijs van Soest; Adrien E. Desjardins

doi:10.1016/j.sna.2021.113162

Fibre optic intravascular measurements of blood flow: A review

Eleanor C. Mackle, Joanna M. Coote, Elizabeth Carr, Callum D. Little, Gijs van Soest, Adrien E. Desjardins^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Review article › Academic › peer-review

3 Citations (Scopus)

Abstract

Fibre optic sensors are well suited to measuring fluid flow in many contexts, and recently there has been burgeoning interest in their application to direct, invasive measurement of blood flow within human vasculature. Depending on the sensing method used and assumptions made, these intravascular measurements of blood flow can provide information about local blood velocity, volumetric flow, and flow-derived parameters. Fibre optic sensors can be readily integrated into medical devices, which are positioned into arteries and veins to obtain measurements that are inaccessible or cumbersome using non-invasive imaging modalities. Measurements of flow within coronary arteries is a particularly promising application of fibre optic sensing; recent studies have demonstrated the clinical utility of certain flow-based parameters, such as the coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). In this review, research and development of fibre optic flow sensors relevant to intravascular flow measurements are reviewed, with a particular focus on biomedical clinical translation.

Original language	English
Article number	113162
Journal	Sensors and Actuators A: Physical
Volume	332
DOIs	https://doi.org/10.1016/j.sna.2021.113162
Publication status	Published - 1 Dec 2021

Bibliographical note

Funding Information:
The authors gratefully acknowledge insightful feedback from Dr. Malcolm Finlay (Barts Hearts Centre, St Bartholomew's Hospital, London, UK), and from the peer review process. Funding was provided by the National Institute for Health Research UCL Biomedical Research Centre and the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) ( 203145Z/16/Z ; NS/A000050/1 ).

Publisher Copyright:
© 2021 The Authors

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title = "Fibre optic intravascular measurements of blood flow: A review",

abstract = "Fibre optic sensors are well suited to measuring fluid flow in many contexts, and recently there has been burgeoning interest in their application to direct, invasive measurement of blood flow within human vasculature. Depending on the sensing method used and assumptions made, these intravascular measurements of blood flow can provide information about local blood velocity, volumetric flow, and flow-derived parameters. Fibre optic sensors can be readily integrated into medical devices, which are positioned into arteries and veins to obtain measurements that are inaccessible or cumbersome using non-invasive imaging modalities. Measurements of flow within coronary arteries is a particularly promising application of fibre optic sensing; recent studies have demonstrated the clinical utility of certain flow-based parameters, such as the coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). In this review, research and development of fibre optic flow sensors relevant to intravascular flow measurements are reviewed, with a particular focus on biomedical clinical translation.",

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AU - van Soest, Gijs

AU - Desjardins, Adrien E.

N1 - Funding Information: The authors gratefully acknowledge insightful feedback from Dr. Malcolm Finlay (Barts Hearts Centre, St Bartholomew's Hospital, London, UK), and from the peer review process. Funding was provided by the National Institute for Health Research UCL Biomedical Research Centre and the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) ( 203145Z/16/Z ; NS/A000050/1 ). Publisher Copyright: © 2021 The Authors

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N2 - Fibre optic sensors are well suited to measuring fluid flow in many contexts, and recently there has been burgeoning interest in their application to direct, invasive measurement of blood flow within human vasculature. Depending on the sensing method used and assumptions made, these intravascular measurements of blood flow can provide information about local blood velocity, volumetric flow, and flow-derived parameters. Fibre optic sensors can be readily integrated into medical devices, which are positioned into arteries and veins to obtain measurements that are inaccessible or cumbersome using non-invasive imaging modalities. Measurements of flow within coronary arteries is a particularly promising application of fibre optic sensing; recent studies have demonstrated the clinical utility of certain flow-based parameters, such as the coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). In this review, research and development of fibre optic flow sensors relevant to intravascular flow measurements are reviewed, with a particular focus on biomedical clinical translation.

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Fibre optic intravascular measurements of blood flow: A review

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