Fibronectin in Fracture Healing: Biological Mechanisms and Regenerative Avenues

Jonathan Klavert, Bram C.J. van der Eerden*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

19 Citations (Scopus)
27 Downloads (Pure)


The importance of extracellular matrix (ECM) proteins in mediating bone fracture repair is evident, and fibronectin (FN) has emerged as a pivotal regulator of this process. FN is an evolutionarily conserved glycoprotein found in all tissues of the body, and functions in several stages of fracture healing. FN acts as a three-dimensional scaffold immediately following trauma, guiding the assembly of additional ECM components. Furthermore, FN regulates cellular behavior via integrin-binding and growth factor-binding domains, promoting downstream responses including cell recruitment, proliferation and differentiation. Due to its diverse functions, the development of FN-based strategies to promote fracture healing is under intense research. In this review, we discuss the recent advancements in utilizing FN-based biomaterials, showing promise in tissue engineering and regenerative medicine applications.

Original languageEnglish
Article number663357
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 16 Apr 2021

Bibliographical note

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© Copyright © 2021 Klavert and van der Eerden.


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