Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

A Mahajan; D Taliun; M Thurner; NR Robertson; JM Torres; NW Rayner; AJ Payne; V Steinthorsdottir; RA Scott; N Grarup; J P Cook; EM Schmidt; M Wuttke; C Sarnowski; R Magill; Jana Nano; C Gieger; S Trompet; C Lecoeur; MH Preuss; BP Prins; XQ Guo; LF Bielak; JE Below; DW Bowden; JC Chambers; YJ Kim; MCY Ng; LE Petty; XL Sim; WH Zhang; AJ Bennett; J Bork-Jensen; C M Brummett; M Canouil; KUE Kardt; K Fischer; SLR Kardia; F Kronenberg; K Lall; CT Liu; AE Locke; JA Luan; L Ntalla; V Nylander; S Schonherr; C Schurmann; L Yengo; EP Bottinger; I Brandslund; C Christensen; G Dedoussis; JC Florez; I Ford; OH Franco Duran; TM Frayling; V Giedraitis; S Hackinger; AT Hattersley; C Herder; Arfan Ikram; M Ingelsson; ME Jorgensen; T Jorgensen; J Kriebel; J Kuusisto; Symen Ligthart; CM Lindgren; A Linneberg; V Lyssenko; V Mamakou; T Meitinger; KL Mohlke; AD Morris; G Nadkarni; JS Pankow; A Peters; N Sattar; A Stancakova; K Strauch; KD Taylor; B Thorand; G Thorleifsson; U Thorsteinsdottir; J Tuomilehto; DR Witte; J Dupuis; PA Peyser; E Zeggini; RJF Loos; P Froguel; E Ingelsson; L Lind; L Groop; M Laakso; FS Collins; JW Jukema; CNA Palmer; H Grallert; A Metspalu; Abbas Dehghan; A Kottgen; GR Abecasis; JB Meigs; JI Rotter; J Marchini; O Pedersen; T Hansen; C Langenberg; NJ Wareham; K Stefansson; AL Gloyn; AP Morris; M Boehnke; MI McCarthy

doi:10.1038/s41588-018-0241-6

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, AJ Payne, V Steinthorsdottir, RA Scott, N Grarup, J P Cook, EM Schmidt, M Wuttke, C Sarnowski, R Magill, Jana Nano, C Gieger, S Trompet, C Lecoeur, MH PreussBP Prins, XQ Guo, LF Bielak, JE Below, DW Bowden, JC Chambers, YJ Kim, MCY Ng, LE Petty, XL Sim, WH Zhang, AJ Bennett, J Bork-Jensen, C M Brummett, M Canouil, KUE Kardt, K Fischer, SLR Kardia, F Kronenberg, K Lall, CT Liu, AE Locke, JA Luan, L Ntalla, V Nylander, S Schonherr, C Schurmann, L Yengo, EP Bottinger, I Brandslund, C Christensen, G Dedoussis, JC Florez, I Ford, OH Franco Duran, TM Frayling, V Giedraitis, S Hackinger, AT Hattersley, C Herder, Arfan Ikram, M Ingelsson, ME Jorgensen, T Jorgensen, J Kriebel, J Kuusisto, Symen Ligthart, CM Lindgren, A Linneberg, V Lyssenko, V Mamakou, T Meitinger, KL Mohlke, AD Morris, G Nadkarni, JS Pankow, A Peters, N Sattar, A Stancakova, K Strauch, KD Taylor, B Thorand, G Thorleifsson, U Thorsteinsdottir, J Tuomilehto, DR Witte, J Dupuis, PA Peyser, E Zeggini, RJF Loos, P Froguel, E Ingelsson, L Lind, L Groop, M Laakso, FS Collins, JW Jukema, CNA Palmer, H Grallert, A Metspalu, Abbas Dehghan, A Kottgen, GR Abecasis, JB Meigs, JI Rotter, J Marchini, O Pedersen, T Hansen, C Langenberg, NJ Wareham, K Stefansson, AL Gloyn, AP Morris, M Boehnke, MI McCarthy

Epidemiology

Research output: Contribution to journal › Article › Academic › peer-review

543 Citations (Scopus)

Original language	English
Pages (from-to)	1505-+
Journal	Nature Genetics
Volume	50
Issue number	11
DOIs	https://doi.org/10.1038/s41588-018-0241-6
Publication status	Published - 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41588-018-0241-6

http://hdl.handle.net/1765/112372

Cite this

Mahajan, A., Taliun, D., Thurner, M., Robertson, NR., Torres, JM., Rayner, NW., Payne, AJ., Steinthorsdottir, V., Scott, RA., Grarup, N., Cook, J. P., Schmidt, EM., Wuttke, M., Sarnowski, C., Magill, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., ... McCarthy, MI. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50(11), 1505-+. https://doi.org/10.1038/s41588-018-0241-6

Mahajan, A ; Taliun, D ; Thurner, M ; Robertson, NR ; Torres, JM ; Rayner, NW ; Payne, AJ ; Steinthorsdottir, V ; Scott, RA ; Grarup, N ; Cook, J P ; Schmidt, EM ; Wuttke, M ; Sarnowski, C ; Magill, R ; Nano, Jana ; Gieger, C ; Trompet, S ; Lecoeur, C ; Preuss, MH ; Prins, BP ; Guo, XQ ; Bielak, LF ; Below, JE ; Bowden, DW ; Chambers, JC ; Kim, YJ ; Ng, MCY ; Petty, LE ; Sim, XL ; Zhang, WH ; Bennett, AJ ; Bork-Jensen, J ; Brummett, C M ; Canouil, M ; Kardt, KUE ; Fischer, K ; Kardia, SLR ; Kronenberg, F ; Lall, K ; Liu, CT ; Locke, AE ; Luan, JA ; Ntalla, L ; Nylander, V ; Schonherr, S ; Schurmann, C ; Yengo, L ; Bottinger, EP ; Brandslund, I ; Christensen, C ; Dedoussis, G ; Florez, JC ; Ford, I ; Franco Duran, OH ; Frayling, TM ; Giedraitis, V ; Hackinger, S ; Hattersley, AT ; Herder, C ; Ikram, Arfan ; Ingelsson, M ; Jorgensen, ME ; Jorgensen, T ; Kriebel, J ; Kuusisto, J ; Ligthart, Symen ; Lindgren, CM ; Linneberg, A ; Lyssenko, V ; Mamakou, V ; Meitinger, T ; Mohlke, KL ; Morris, AD ; Nadkarni, G ; Pankow, JS ; Peters, A ; Sattar, N ; Stancakova, A ; Strauch, K ; Taylor, KD ; Thorand, B ; Thorleifsson, G ; Thorsteinsdottir, U ; Tuomilehto, J ; Witte, DR ; Dupuis, J ; Peyser, PA ; Zeggini, E ; Loos, RJF ; Froguel, P ; Ingelsson, E ; Lind, L ; Groop, L ; Laakso, M ; Collins, FS ; Jukema, JW ; Palmer, CNA ; Grallert, H ; Metspalu, A ; Dehghan, Abbas ; Kottgen, A ; Abecasis, GR ; Meigs, JB ; Rotter, JI ; Marchini, J ; Pedersen, O ; Hansen, T ; Langenberg, C ; Wareham, NJ ; Stefansson, K ; Gloyn, AL ; Morris, AP ; Boehnke, M ; McCarthy, MI. / Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. In: Nature Genetics. 2018 ; Vol. 50, No. 11. pp. 1505-+.

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title = "Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps",

author = "A Mahajan and D Taliun and M Thurner and NR Robertson and JM Torres and NW Rayner and AJ Payne and V Steinthorsdottir and RA Scott and N Grarup and Cook, {J P} and EM Schmidt and M Wuttke and C Sarnowski and R Magill and Jana Nano and C Gieger and S Trompet and C Lecoeur and MH Preuss and BP Prins and XQ Guo and LF Bielak and JE Below and DW Bowden and JC Chambers and YJ Kim and MCY Ng and LE Petty and XL Sim and WH Zhang and AJ Bennett and J Bork-Jensen and Brummett, {C M} and M Canouil and KUE Kardt and K Fischer and SLR Kardia and F Kronenberg and K Lall and CT Liu and AE Locke and JA Luan and L Ntalla and V Nylander and S Schonherr and C Schurmann and L Yengo and EP Bottinger and I Brandslund and C Christensen and G Dedoussis and JC Florez and I Ford and {Franco Duran}, OH and TM Frayling and V Giedraitis and S Hackinger and AT Hattersley and C Herder and Arfan Ikram and M Ingelsson and ME Jorgensen and T Jorgensen and J Kriebel and J Kuusisto and Symen Ligthart and CM Lindgren and A Linneberg and V Lyssenko and V Mamakou and T Meitinger and KL Mohlke and AD Morris and G Nadkarni and JS Pankow and A Peters and N Sattar and A Stancakova and K Strauch and KD Taylor and B Thorand and G Thorleifsson and U Thorsteinsdottir and J Tuomilehto and DR Witte and J Dupuis and PA Peyser and E Zeggini and RJF Loos and P Froguel and E Ingelsson and L Lind and L Groop and M Laakso and FS Collins and JW Jukema and CNA Palmer and H Grallert and A Metspalu and Abbas Dehghan and A Kottgen and GR Abecasis and JB Meigs and JI Rotter and J Marchini and O Pedersen and T Hansen and C Langenberg and NJ Wareham and K Stefansson and AL Gloyn and AP Morris and M Boehnke and MI McCarthy",

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Mahajan, A, Taliun, D, Thurner, M, Robertson, NR, Torres, JM, Rayner, NW, Payne, AJ, Steinthorsdottir, V, Scott, RA, Grarup, N, Cook, JP, Schmidt, EM, Wuttke, M, Sarnowski, C, Magill, R, Nano, J, Gieger, C, Trompet, S, Lecoeur, C, Preuss, MH, Prins, BP, Guo, XQ, Bielak, LF, Below, JE, Bowden, DW, Chambers, JC, Kim, YJ, Ng, MCY, Petty, LE, Sim, XL, Zhang, WH, Bennett, AJ, Bork-Jensen, J, Brummett, CM, Canouil, M, Kardt, KUE, Fischer, K, Kardia, SLR, Kronenberg, F, Lall, K, Liu, CT, Locke, AE, Luan, JA, Ntalla, L, Nylander, V, Schonherr, S, Schurmann, C, Yengo, L, Bottinger, EP, Brandslund, I, Christensen, C, Dedoussis, G, Florez, JC, Ford, I, Franco Duran, OH, Frayling, TM, Giedraitis, V, Hackinger, S, Hattersley, AT, Herder, C, Ikram, A, Ingelsson, M, Jorgensen, ME, Jorgensen, T, Kriebel, J, Kuusisto, J, Ligthart, S, Lindgren, CM, Linneberg, A, Lyssenko, V, Mamakou, V, Meitinger, T, Mohlke, KL, Morris, AD, Nadkarni, G, Pankow, JS, Peters, A, Sattar, N, Stancakova, A, Strauch, K, Taylor, KD, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tuomilehto, J, Witte, DR, Dupuis, J, Peyser, PA, Zeggini, E, Loos, RJF, Froguel, P, Ingelsson, E, Lind, L, Groop, L, Laakso, M, Collins, FS, Jukema, JW, Palmer, CNA, Grallert, H, Metspalu, A, Dehghan, A, Kottgen, A, Abecasis, GR, Meigs, JB, Rotter, JI, Marchini, J, Pedersen, O, Hansen, T, Langenberg, C, Wareham, NJ, Stefansson, K, Gloyn, AL, Morris, AP, Boehnke, M & McCarthy, MI 2018, 'Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps', Nature Genetics, vol. 50, no. 11, pp. 1505-+. https://doi.org/10.1038/s41588-018-0241-6

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. / Mahajan, A; Taliun, D; Thurner, M; Robertson, NR; Torres, JM; Rayner, NW; Payne, AJ; Steinthorsdottir, V; Scott, RA; Grarup, N; Cook, J P; Schmidt, EM; Wuttke, M; Sarnowski, C; Magill, R; Nano, Jana; Gieger, C; Trompet, S; Lecoeur, C; Preuss, MH; Prins, BP; Guo, XQ; Bielak, LF; Below, JE; Bowden, DW; Chambers, JC; Kim, YJ; Ng, MCY; Petty, LE; Sim, XL; Zhang, WH; Bennett, AJ; Bork-Jensen, J; Brummett, C M; Canouil, M; Kardt, KUE; Fischer, K; Kardia, SLR; Kronenberg, F; Lall, K; Liu, CT; Locke, AE; Luan, JA; Ntalla, L; Nylander, V; Schonherr, S; Schurmann, C; Yengo, L; Bottinger, EP; Brandslund, I; Christensen, C; Dedoussis, G; Florez, JC; Ford, I; Franco Duran, OH; Frayling, TM; Giedraitis, V; Hackinger, S; Hattersley, AT; Herder, C; Ikram, Arfan; Ingelsson, M; Jorgensen, ME; Jorgensen, T; Kriebel, J; Kuusisto, J; Ligthart, Symen; Lindgren, CM; Linneberg, A; Lyssenko, V; Mamakou, V; Meitinger, T; Mohlke, KL; Morris, AD; Nadkarni, G; Pankow, JS; Peters, A; Sattar, N; Stancakova, A; Strauch, K; Taylor, KD; Thorand, B; Thorleifsson, G; Thorsteinsdottir, U; Tuomilehto, J; Witte, DR; Dupuis, J; Peyser, PA; Zeggini, E; Loos, RJF; Froguel, P; Ingelsson, E; Lind, L; Groop, L; Laakso, M; Collins, FS; Jukema, JW; Palmer, CNA; Grallert, H; Metspalu, A; Dehghan, Abbas; Kottgen, A; Abecasis, GR; Meigs, JB; Rotter, JI; Marchini, J; Pedersen, O; Hansen, T; Langenberg, C; Wareham, NJ; Stefansson, K; Gloyn, AL; Morris, AP; Boehnke, M; McCarthy, MI.

In: Nature Genetics, Vol. 50, No. 11, 2018, p. 1505-+.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

AU - Mahajan, A

AU - Taliun, D

AU - Thurner, M

AU - Robertson, NR

AU - Torres, JM

AU - Rayner, NW

AU - Payne, AJ

AU - Steinthorsdottir, V

AU - Scott, RA

AU - Grarup, N

AU - Cook, J P

AU - Schmidt, EM

AU - Wuttke, M

AU - Sarnowski, C

AU - Magill, R

AU - Nano, Jana

AU - Gieger, C

AU - Trompet, S

AU - Lecoeur, C

AU - Preuss, MH

AU - Prins, BP

AU - Guo, XQ

AU - Bielak, LF

AU - Below, JE

AU - Bowden, DW

AU - Chambers, JC

AU - Kim, YJ

AU - Ng, MCY

AU - Petty, LE

AU - Sim, XL

AU - Zhang, WH

AU - Bennett, AJ

AU - Bork-Jensen, J

AU - Brummett, C M

AU - Canouil, M

AU - Kardt, KUE

AU - Fischer, K

AU - Kardia, SLR

AU - Kronenberg, F

AU - Lall, K

AU - Liu, CT

AU - Locke, AE

AU - Luan, JA

AU - Ntalla, L

AU - Nylander, V

AU - Schonherr, S

AU - Schurmann, C

AU - Yengo, L

AU - Bottinger, EP

AU - Brandslund, I

AU - Christensen, C

AU - Dedoussis, G

AU - Florez, JC

AU - Ford, I

AU - Franco Duran, OH

AU - Frayling, TM

AU - Giedraitis, V

AU - Hackinger, S

AU - Hattersley, AT

AU - Herder, C

AU - Ikram, Arfan

AU - Ingelsson, M

AU - Jorgensen, ME

AU - Jorgensen, T

AU - Kriebel, J

AU - Kuusisto, J

AU - Ligthart, Symen

AU - Lindgren, CM

AU - Linneberg, A

AU - Lyssenko, V

AU - Mamakou, V

AU - Meitinger, T

AU - Mohlke, KL

AU - Morris, AD

AU - Nadkarni, G

AU - Pankow, JS

AU - Peters, A

AU - Sattar, N

AU - Stancakova, A

AU - Strauch, K

AU - Taylor, KD

AU - Thorand, B

AU - Thorleifsson, G

AU - Thorsteinsdottir, U

AU - Tuomilehto, J

AU - Witte, DR

AU - Dupuis, J

AU - Peyser, PA

AU - Zeggini, E

AU - Loos, RJF

AU - Froguel, P

AU - Ingelsson, E

AU - Lind, L

AU - Groop, L

AU - Laakso, M

AU - Collins, FS

AU - Jukema, JW

AU - Palmer, CNA

AU - Grallert, H

AU - Metspalu, A

AU - Dehghan, Abbas

AU - Kottgen, A

AU - Abecasis, GR

AU - Meigs, JB

AU - Rotter, JI

AU - Marchini, J

AU - Pedersen, O

AU - Hansen, T

AU - Langenberg, C

AU - Wareham, NJ

AU - Stefansson, K

AU - Gloyn, AL

AU - Morris, AP

AU - Boehnke, M

AU - McCarthy, MI

PY - 2018

Y1 - 2018

U2 - 10.1038/s41588-018-0241-6

DO - 10.1038/s41588-018-0241-6

M3 - Article

VL - 50

SP - 1505-+

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -