First trimester fetal proportion volumetric measurements using a Virtual Reality approach

Clarissa J. Wiertsema; Jan S. Erkamp; Annemarie G.M.G.J. Mulders; Eric A.P. Steegers; Liesbeth Duijts; Anton H.J. Koning; Romy Gaillard; Vincent W.V. Jaddoe

doi:10.1002/pd.5947

First trimester fetal proportion volumetric measurements using a Virtual Reality approach

Clarissa J. Wiertsema, Jan S. Erkamp, Annemarie G.M.G.J. Mulders, Eric A.P. Steegers, Liesbeth Duijts, Anton H.J. Koning, Romy Gaillard, Vincent W.V. Jaddoe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: To establish feasibility and reproducibility of fetal proportion volumetric measurements, using three-dimensional (3D) ultrasound and a Virtual Reality (VR) system. Methods: Within a population-based prospective birth cohort, 3D ultrasound datasets of 50 fetuses in the late first trimester were collected by three ultrasonographers in a single research center. V-scope software was used for volumetric measurements of total fetus, extremities, head-trunk, head, trunk, thorax, and abdomen. All measurements were performed independently by two researchers. Intraobserver and interobserver reproducibility were analyzed using Bland and Altman methods. Results: Intraobserver and interobserver analyses of volumetric measurements of total fetus, head-trunk, head, trunk, thorax and abdomen showed intraclass correlation coefficients above 0.979, coefficients of variation below 7.51% and mean difference below 3.44%. The interobserver limits of agreement were within the ±10% range for volumetric measurements of total fetus, head–trunk, head and trunk. The interobserver limits of agreement for extremities, thorax and abdomen were −26.09% to 4.77%, −14.14% to 10.00% and −14.47% to 8.83%, respectively. Conclusion: First trimester fetal proportion volumetric measurements using 3D ultrasound and VR are feasible and reproducible, except volumetric measurements of the fetal extremities. These novel volumetric measurements may be used in future research to enable detailed studies on first trimester fetal development and growth.

Original language	English
Pages (from-to)	868-876
Number of pages	9
Journal	Prenatal Diagnosis
Volume	41
Issue number	7
Early online date	3 Apr 2021
DOIs	https://doi.org/10.1002/pd.5947
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
The Generation R Next Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC-2014-CoG-648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109).

Funding Information:
The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC‐2014‐CoG‐648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN‐Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109). Next

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© 2021 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.

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EMC MM-04-54-08-A
EMC MM-03-54-04-A
EMC OR-01-54-02

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Cite this

@article{bc2ab6e0b5174773af0a36df0d7636fa,

title = "First trimester fetal proportion volumetric measurements using a Virtual Reality approach",

abstract = "Objective: To establish feasibility and reproducibility of fetal proportion volumetric measurements, using three-dimensional (3D) ultrasound and a Virtual Reality (VR) system. Methods: Within a population-based prospective birth cohort, 3D ultrasound datasets of 50 fetuses in the late first trimester were collected by three ultrasonographers in a single research center. V-scope software was used for volumetric measurements of total fetus, extremities, head-trunk, head, trunk, thorax, and abdomen. All measurements were performed independently by two researchers. Intraobserver and interobserver reproducibility were analyzed using Bland and Altman methods. Results: Intraobserver and interobserver analyses of volumetric measurements of total fetus, head-trunk, head, trunk, thorax and abdomen showed intraclass correlation coefficients above 0.979, coefficients of variation below 7.51% and mean difference below 3.44%. The interobserver limits of agreement were within the ±10% range for volumetric measurements of total fetus, head–trunk, head and trunk. The interobserver limits of agreement for extremities, thorax and abdomen were −26.09% to 4.77%, −14.14% to 10.00% and −14.47% to 8.83%, respectively. Conclusion: First trimester fetal proportion volumetric measurements using 3D ultrasound and VR are feasible and reproducible, except volumetric measurements of the fetal extremities. These novel volumetric measurements may be used in future research to enable detailed studies on first trimester fetal development and growth.",

author = "Wiertsema, {Clarissa J.} and Erkamp, {Jan S.} and Mulders, {Annemarie G.M.G.J.} and Steegers, {Eric A.P.} and Liesbeth Duijts and Koning, {Anton H.J.} and Romy Gaillard and Jaddoe, {Vincent W.V.}",

note = "Funding Information: The Generation R Next Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC-2014-CoG-648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109). Funding Information: The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC‐2014‐CoG‐648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN‐Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109). Next Publisher Copyright: {\textcopyright} 2021 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.",

year = "2021",

month = jun,

doi = "10.1002/pd.5947",

language = "English",

volume = "41",

pages = "868--876",

journal = "Prenatal Diagnosis",

issn = "0197-3851",

publisher = "John Wiley & Sons Ltd.",

number = "7",

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TY - JOUR

T1 - First trimester fetal proportion volumetric measurements using a Virtual Reality approach

AU - Wiertsema, Clarissa J.

AU - Erkamp, Jan S.

AU - Mulders, Annemarie G.M.G.J.

AU - Steegers, Eric A.P.

AU - Duijts, Liesbeth

AU - Koning, Anton H.J.

AU - Gaillard, Romy

AU - Jaddoe, Vincent W.V.

N1 - Funding Information: The Generation R Next Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC-2014-CoG-648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109). Funding Information: The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, fathers, general practitioners, midwives, hospitals and pharmacies in Rotterdam. The Generation R Next Study was financially supported by the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent V.W. Jaddoe received a grant from the European Research Council (Consolidator Grant, ERC‐2014‐CoG‐648916). Vincent V.W. Jaddoe and Liesbeth Duijts received funding for projects from European Union's Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no 733206, 2016; EUCAN‐Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). Dr. Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013), the Dutch Diabetes Foundation (grant number 2017.81.002) and the Netherlands Organization for Health Research and Development (NWO, ZonMW, grant number 543003109). Next Publisher Copyright: © 2021 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.

PY - 2021/6

Y1 - 2021/6

N2 - Objective: To establish feasibility and reproducibility of fetal proportion volumetric measurements, using three-dimensional (3D) ultrasound and a Virtual Reality (VR) system. Methods: Within a population-based prospective birth cohort, 3D ultrasound datasets of 50 fetuses in the late first trimester were collected by three ultrasonographers in a single research center. V-scope software was used for volumetric measurements of total fetus, extremities, head-trunk, head, trunk, thorax, and abdomen. All measurements were performed independently by two researchers. Intraobserver and interobserver reproducibility were analyzed using Bland and Altman methods. Results: Intraobserver and interobserver analyses of volumetric measurements of total fetus, head-trunk, head, trunk, thorax and abdomen showed intraclass correlation coefficients above 0.979, coefficients of variation below 7.51% and mean difference below 3.44%. The interobserver limits of agreement were within the ±10% range for volumetric measurements of total fetus, head–trunk, head and trunk. The interobserver limits of agreement for extremities, thorax and abdomen were −26.09% to 4.77%, −14.14% to 10.00% and −14.47% to 8.83%, respectively. Conclusion: First trimester fetal proportion volumetric measurements using 3D ultrasound and VR are feasible and reproducible, except volumetric measurements of the fetal extremities. These novel volumetric measurements may be used in future research to enable detailed studies on first trimester fetal development and growth.

AB - Objective: To establish feasibility and reproducibility of fetal proportion volumetric measurements, using three-dimensional (3D) ultrasound and a Virtual Reality (VR) system. Methods: Within a population-based prospective birth cohort, 3D ultrasound datasets of 50 fetuses in the late first trimester were collected by three ultrasonographers in a single research center. V-scope software was used for volumetric measurements of total fetus, extremities, head-trunk, head, trunk, thorax, and abdomen. All measurements were performed independently by two researchers. Intraobserver and interobserver reproducibility were analyzed using Bland and Altman methods. Results: Intraobserver and interobserver analyses of volumetric measurements of total fetus, head-trunk, head, trunk, thorax and abdomen showed intraclass correlation coefficients above 0.979, coefficients of variation below 7.51% and mean difference below 3.44%. The interobserver limits of agreement were within the ±10% range for volumetric measurements of total fetus, head–trunk, head and trunk. The interobserver limits of agreement for extremities, thorax and abdomen were −26.09% to 4.77%, −14.14% to 10.00% and −14.47% to 8.83%, respectively. Conclusion: First trimester fetal proportion volumetric measurements using 3D ultrasound and VR are feasible and reproducible, except volumetric measurements of the fetal extremities. These novel volumetric measurements may be used in future research to enable detailed studies on first trimester fetal development and growth.

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EP - 876

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

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First trimester fetal proportion volumetric measurements using a Virtual Reality approach

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