First trimester interleukin 8 levels are associated with postpartum relapse in multiple sclerosis

Rinze Neuteboom, Evert Verbraak, Jane Voerman, Marjan van Meurs, Eric Steegers, CJM de Groot, Jon Laman, Rogier Hintzen

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20 Citations (Scopus)


Pregnancy has an ameliorating effect on multiple sclerosis (MS), but directly after delivery the risk of a relapse is increased. The pro-inflammatory chemokine interleukin 8 is associated with disease activity. We aimed to investigate whether pregnancy-induced fluctuations of interleukin 8 correlate with periods of enhanced and diminished disease activity. Thirty-six women with MS were prospectively studied before, during and after pregnancy. Serum levels of interleukin 8 were significantly decreased during the third trimester (p = 0.03). High first trimester serum levels of interleukin 8 were associated with a high risk of postpartum relapse (p = 0.007). These results help us to further understand the altered disease course during pregnancy.
Original languageUndefined/Unknown
Pages (from-to)1356-1358
Number of pages3
JournalMultiple Sclerosis
Issue number11
Publication statusPublished - 2009

Research programs

  • EMC MGC-02-52-01-A
  • EMC MM-02-72-02
  • EMC MM-04-44-02

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