First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort

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Abstract

Objective: 

To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. 

Methods: 

In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA. 

Results: 

A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies. 

Conclusion: 

The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.

Original languageEnglish
Article number2238086
JournalHypertension in Pregnancy
Volume42
Issue number1
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
The department of Obstetrics and Gynecology and the Bo Hjelt Foundation for Spina Bifida in memory of Madeleine Hjelt provided financial support for the conduct of the study and preparation of the manuscript. The funding source had no involvement in study design, data collection, analysis, and interpretation of data, in the writing of the report nor in the decision to submit this article for publication. The authors wish to thank Pascal. P. Arp from the Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, the Netherlands, for executing the telomere length measurements. The authors wish to gratefully acknowledge the Rotterdam Periconceptional Cohort team for data acquisition and thank the participants for their contributions.

Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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