Flavonoids: a review of probable mechanisms of action and potential applications

R J Nijveldt, E van Nood, D E van Hoorn, P G Boelens, K van Norren, P A van Leeuwen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2544 Citations (Scopus)


The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances. Flavonoids occur naturally in fruit, vegetables, and beverages such as tea and wine. Research in the field of flavonoids has increased since the discovery of the French paradox,ie, the low cardiovascular mortality rate observed in Mediterranean populations in association with red wine consumption and a high saturated fat intake. Several other potential beneficial properties of flavonoids have since been ascertained. We review the different groups of known flavonoids, the probable mechanisms by which they act, and the potential clinical applications of these fascinating natural substances.

Original languageEnglish
Pages (from-to)418-25
Number of pages8
JournalThe American journal of clinical nutrition
Issue number4
Publication statusPublished - Oct 2001


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