Fluctuations of MS births and UV-light exposure

F. Verheul; J. Smolders; M. Trojano; V. Lepore; C. Zwanikken; M. P. Amato; F. Grand'Maison; H. Butzkueven; M. Marrosu; P. Duquette; G. Comi; G. Izquierdo; P. Grammond; G. Lus; T. Petersen; R. Bergamaschi; G. Giuliani; C. Boz; G. Coniglio; V. Van Pesch; J. Lechner-Scott; P. Cavalla; F. Granella; C. Avolio; M. Fiol; D. Poehlau; M. L. Saladino; P. Gallo; N. Deri; W. Oleschko Arruda; M. Paine; M. Ferro; M. Barnett; J. A. Cabrera-Gomez; M. Slee; F. Moore; C. Shaw; T. Petkovska-Boskova; M. Rutherford; O. Engelsen; J. Damoiseaux; R. Hupperts

doi:10.1111/ane.12007

Fluctuations of MS births and UV-light exposure

F. Verheul^*
, J. Smolders
, M. Trojano
, V. Lepore
, C. Zwanikken
, M. P. Amato
, F. Grand'Maison
, H. Butzkueven
, M. Marrosu
, P. Duquette
, G. Comi
, G. Izquierdo
, P. Grammond
, G. Lus
, T. Petersen
, R. Bergamaschi
, G. Giuliani
, C. Boz
, G. Coniglio
, V. Van Pesch

J. Lechner-Scott, P. Cavalla, F. Granella, C. Avolio, M. Fiol, D. Poehlau, M. L. Saladino, P. Gallo, N. Deri, W. Oleschko Arruda, M. Paine, M. Ferro, M. Barnett, J. A. Cabrera-Gomez, M. Slee, F. Moore, C. Shaw, T. Petkovska-Boskova, M. Rutherford, O. Engelsen, J. Damoiseaux, R. Hupperts

^*Corresponding author for this work

Groene Hart Ziekenhuis
University of Bari Aldo Moro
IRCCS Istituto di ricerche farmacologiche Mario Negri - Milano, Bergamo, Ranica
MS-centrum Nijmegen
Université de Sherbrooke
University of Melbourne
University of Cagliari
University of Montreal
University of Milan
Hospital Universitario de Valme
Hotel-Dieu de Levis Hospital
University of Campania Luigi Vanvitelli
University of Pavia
Ospedale di Marcerata
Karadeniz Technical University
Ospedale di Matera
Cliniques Universitaires Saint-Luc
Hunter New England Health
University of Turin
University of Parma
University of Foggia
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
not available
INEBA
University of Padua
Hospital General de Agudos Juan Fernandez
Hospital Ecoville
St. Vincent's Hospital Melbourne
Ospedale Maggiore
University of Sydney
Centro Internacional de Restauracion Neurologica
Flinders Medical Centre
McGill University
Barwon Health
Clinic of Neurology Clinical Center
MSBase Foundation
Norwegian Institute for Air Research
Maastricht University Medical Centre
Orbis Medical Centre
Zuyderland Medical Center (Sittard-Geleen)
University of Florence
Kommunehospitalet, Århus

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

36 Downloads (Pure)

Abstract

Background: Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon. Aim: To assess the correlation between fluctuation of sunlight and birth season in persons with MS. Methods: For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births. Results: Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ²= 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (P_trend= 0.086). Conclusion: Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.

Original language	English
Pages (from-to)	301-308
Number of pages	8
Journal	Acta Neurologica Scandinavica
Volume	127
Issue number	5
DOIs	https://doi.org/10.1111/ane.12007
Publication status	Published - May 2013
Externally published	Yes

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Verheul, F., Smolders, J., Trojano, M., Lepore, V., Zwanikken, C., Amato, M. P., Grand'Maison, F., Butzkueven, H., Marrosu, M., Duquette, P., Comi, G., Izquierdo, G., Grammond, P., Lus, G., Petersen, T., Bergamaschi, R., Giuliani, G., Boz, C., Coniglio, G., ... Hupperts, R. (2013). Fluctuations of MS births and UV-light exposure. Acta Neurologica Scandinavica, 127(5), 301-308. https://doi.org/10.1111/ane.12007

@article{ca9d658ebd4c417f9e71d53abe059792,

title = "Fluctuations of MS births and UV-light exposure",

abstract = "Background: Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon. Aim: To assess the correlation between fluctuation of sunlight and birth season in persons with MS. Methods: For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births. Results: Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ2 = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086). Conclusion: Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.",

author = "F. Verheul and J. Smolders and M. Trojano and V. Lepore and C. Zwanikken and Amato, \{M. P.\} and F. Grand'Maison and H. Butzkueven and M. Marrosu and P. Duquette and G. Comi and G. Izquierdo and P. Grammond and G. Lus and T. Petersen and R. Bergamaschi and G. Giuliani and C. Boz and G. Coniglio and \{Van Pesch\}, V. and J. Lechner-Scott and P. Cavalla and F. Granella and C. Avolio and M. Fiol and D. Poehlau and Saladino, \{M. L.\} and P. Gallo and N. Deri and \{Oleschko Arruda\}, W. and M. Paine and M. Ferro and M. Barnett and Cabrera-Gomez, \{J. A.\} and M. Slee and F. Moore and C. Shaw and T. Petkovska-Boskova and M. Rutherford and O. Engelsen and J. Damoiseaux and R. Hupperts",

year = "2013",

month = may,

doi = "10.1111/ane.12007",

language = "English",

volume = "127",

pages = "301--308",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "John Wiley \& Sons Inc.",

number = "5",

}

Verheul, F, Smolders, J, Trojano, M, Lepore, V, Zwanikken, C, Amato, MP, Grand'Maison, F, Butzkueven, H, Marrosu, M, Duquette, P, Comi, G, Izquierdo, G, Grammond, P, Lus, G, Petersen, T, Bergamaschi, R, Giuliani, G, Boz, C, Coniglio, G, Van Pesch, V, Lechner-Scott, J, Cavalla, P, Granella, F, Avolio, C, Fiol, M, Poehlau, D, Saladino, ML, Gallo, P, Deri, N, Oleschko Arruda, W, Paine, M, Ferro, M, Barnett, M, Cabrera-Gomez, JA, Slee, M, Moore, F, Shaw, C, Petkovska-Boskova, T, Rutherford, M, Engelsen, O, Damoiseaux, J & Hupperts, R 2013, 'Fluctuations of MS births and UV-light exposure', Acta Neurologica Scandinavica, vol. 127, no. 5, pp. 301-308. https://doi.org/10.1111/ane.12007

TY - JOUR

T1 - Fluctuations of MS births and UV-light exposure

AU - Verheul, F.

AU - Smolders, J.

AU - Trojano, M.

AU - Lepore, V.

AU - Zwanikken, C.

AU - Amato, M. P.

AU - Grand'Maison, F.

AU - Butzkueven, H.

AU - Marrosu, M.

AU - Duquette, P.

AU - Comi, G.

AU - Izquierdo, G.

AU - Grammond, P.

AU - Lus, G.

AU - Petersen, T.

AU - Bergamaschi, R.

AU - Giuliani, G.

AU - Boz, C.

AU - Coniglio, G.

AU - Van Pesch, V.

AU - Lechner-Scott, J.

AU - Cavalla, P.

AU - Granella, F.

AU - Avolio, C.

AU - Fiol, M.

AU - Poehlau, D.

AU - Saladino, M. L.

AU - Gallo, P.

AU - Deri, N.

AU - Oleschko Arruda, W.

AU - Paine, M.

AU - Ferro, M.

AU - Barnett, M.

AU - Cabrera-Gomez, J. A.

AU - Slee, M.

AU - Moore, F.

AU - Shaw, C.

AU - Petkovska-Boskova, T.

AU - Rutherford, M.

AU - Engelsen, O.

AU - Damoiseaux, J.

AU - Hupperts, R.

PY - 2013/5

Y1 - 2013/5

N2 - Background: Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon. Aim: To assess the correlation between fluctuation of sunlight and birth season in persons with MS. Methods: For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births. Results: Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ2 = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086). Conclusion: Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.

AB - Background: Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon. Aim: To assess the correlation between fluctuation of sunlight and birth season in persons with MS. Methods: For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births. Results: Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ2 = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086). Conclusion: Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.

UR - https://www.scopus.com/pages/publications/84878347465

U2 - 10.1111/ane.12007

DO - 10.1111/ane.12007

M3 - Article

C2 - 22970985

AN - SCOPUS:84878347465

SN - 0001-6314

VL - 127

SP - 301

EP - 308

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 5

ER -

Fluctuations of MS births and UV-light exposure

Abstract

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