TY - JOUR
T1 - Footshock-induced sensitization of the acoustic startle response in two strains of mice
AU - Dirks, Anneloes
AU - De Jongh, Reinoud
AU - Groenink, Lucianne
AU - Van Der Gugten, Jan
AU - Hijzen, Theo H.
AU - Olivier, Berend
PY - 2001/8/27
Y1 - 2001/8/27
N2 - It has been shown before that unconditioned footshocks can augment the acoustic startle response in rats. In the present study, male mice of two strains, C57B1/6N and BALB/c, were compared with regard to footshock-induced sensitization of the acoustic startle response. Presentation of footshocks did not affect the acoustic startle response in C57B1/6N mice, while in contrast, footshock-induced sensitization was apparent in the BALB/c strain. Shocked C57B1/6N mice, but not BALB/c mice, displayed robust conditioning to the startle context when re-tested the next day. These findings indicate that mice may exhibit footshock-induced sensitization of the acoustic startle response, but that the effects of footshocks on the acoustic startle are strain- and time-dependent.
AB - It has been shown before that unconditioned footshocks can augment the acoustic startle response in rats. In the present study, male mice of two strains, C57B1/6N and BALB/c, were compared with regard to footshock-induced sensitization of the acoustic startle response. Presentation of footshocks did not affect the acoustic startle response in C57B1/6N mice, while in contrast, footshock-induced sensitization was apparent in the BALB/c strain. Shocked C57B1/6N mice, but not BALB/c mice, displayed robust conditioning to the startle context when re-tested the next day. These findings indicate that mice may exhibit footshock-induced sensitization of the acoustic startle response, but that the effects of footshocks on the acoustic startle are strain- and time-dependent.
UR - http://www.scopus.com/inward/record.url?scp=0035959532&partnerID=8YFLogxK
U2 - 10.1016/S0166-4328(01)00193-0
DO - 10.1016/S0166-4328(01)00193-0
M3 - Article
C2 - 11377726
AN - SCOPUS:0035959532
SN - 0166-4328
VL - 123
SP - 17
EP - 21
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -