Four-dimensional computational ultrasound imaging of brain hemodynamics

Michael D. Brown; Bastian S. Generowicz; Stephanie Dijkhuizen; Sebastiaan K.E. Koekkoek; Christos Strydis; Johannes G. Bosch; Petros Arvanitis; Geert Springeling; Geert J.T. Leus; Chris I. De Zeeuw; Pieter Kruizinga

doi:10.1126/sciadv.adk7957

Four-dimensional computational ultrasound imaging of brain hemodynamics

Michael D. Brown^*, Bastian S. Generowicz, Stephanie Dijkhuizen, Sebastiaan K.E. Koekkoek, Christos Strydis, Johannes G. Bosch, Petros Arvanitis, Geert Springeling, Geert J.T. Leus, Chris I. De Zeeuw, Pieter Kruizinga

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.

Original language	English
Article number	eadk7957
Journal	Science advances
Volume	10
Issue number	3
DOIs	https://doi.org/10.1126/sciadv.adk7957
Publication status	Published - 17 Jan 2024

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© 2024 American Association for the Advancement of Science. All rights reserved.

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Four-dimensional computational ultrasound imaging of brain hemodynamicsFinal published version, 1.47 MBLicence: CC BY

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AU - Generowicz, Bastian S.

AU - Dijkhuizen, Stephanie

AU - Koekkoek, Sebastiaan K.E.

AU - Strydis, Christos

AU - Bosch, Johannes G.

AU - Arvanitis, Petros

AU - Springeling, Geert

AU - Leus, Geert J.T.

AU - De Zeeuw, Chris I.

AU - Kruizinga, Pieter

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AB - Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.

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Four-dimensional computational ultrasound imaging of brain hemodynamics

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