Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

E. Peelen; M. Thewissen; S. Knippenberg; J. Smolders; A. H. Muris; P. Menheere; J. W. Cohen Tervaert; R. Hupperts; J. Damoiseaux

doi:10.1016/j.jneuroim.2013.02.014

Fraction of IL-10⁺ and IL-17⁺ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

E. Peelen^*, M. Thewissen, S. Knippenberg, J. Smolders, A. H. Muris, P. Menheere, J. W. Cohen Tervaert, R. Hupperts, J. Damoiseaux

^*Corresponding author for this work

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Abstract

In the present study, circulating proportions of CD8⁺ T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	258
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.02.014
Publication status	Published - 15 May 2013
Externally published	Yes

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10.1016/j.jneuroim.2013.02.014

Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulatorsFinal published version, 950 KB

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Peelen, E., Thewissen, M., Knippenberg, S., Smolders, J., Muris, A. H., Menheere, P., Cohen Tervaert, J. W., Hupperts, R., & Damoiseaux, J. (2013). Fraction of IL-10⁺ and IL-17⁺ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators. Journal of Neuroimmunology, 258(1-2), 77-84. https://doi.org/10.1016/j.jneuroim.2013.02.014

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abstract = "In the present study, circulating proportions of CD8+ T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.",

author = "E. Peelen and M. Thewissen and S. Knippenberg and J. Smolders and Muris, {A. H.} and P. Menheere and {Cohen Tervaert}, {J. W.} and R. Hupperts and J. Damoiseaux",

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Peelen, E, Thewissen, M, Knippenberg, S, Smolders, J, Muris, AH, Menheere, P, Cohen Tervaert, JW, Hupperts, R & Damoiseaux, J 2013, 'Fraction of IL-10⁺ and IL-17⁺ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators', Journal of Neuroimmunology, vol. 258, no. 1-2, pp. 77-84. https://doi.org/10.1016/j.jneuroim.2013.02.014

TY - JOUR

T1 - Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

AU - Peelen, E.

AU - Thewissen, M.

AU - Knippenberg, S.

AU - Smolders, J.

AU - Muris, A. H.

AU - Menheere, P.

AU - Cohen Tervaert, J. W.

AU - Hupperts, R.

AU - Damoiseaux, J.

PY - 2013/5/15

Y1 - 2013/5/15

N2 - In the present study, circulating proportions of CD8+ T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

AB - In the present study, circulating proportions of CD8+ T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

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U2 - 10.1016/j.jneuroim.2013.02.014

DO - 10.1016/j.jneuroim.2013.02.014

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C2 - 23517930

AN - SCOPUS:84876705798

SN - 0165-5728

VL - 258

SP - 77

EP - 84

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Fraction of IL-10⁺ and IL-17⁺ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

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