Frequency of antithyroid antibodies in patients with primary biliary cholangitis

Mariam Ghozzi; Amani Mankai; Zeineb Chedly; Ikram Mlika; Wiem Manoubi; Sarra Melayah; Ibtissem Ghedira

doi:10.1093/labmed/lmad080

Frequency of antithyroid antibodies in patients with primary biliary cholangitis

Mariam Ghozzi^*
, Amani Mankai
, Zeineb Chedly
, Ikram Mlika
, Wiem Manoubi
, Sarra Melayah
, Ibtissem Ghedira

^*Corresponding author for this work

Neurosciences

University of Sousse
University of Monastir
CHU Sahloul
Université de Tunis El Manar

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

15 Downloads (Pure)

Abstract

OBJECTIVE:

Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti-thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC.

METHODS:

Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab.

RESULTS:

Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7% vs 1.6%; P < 10-3). Out of 11 patients with ATA, 10 (90.9%) were female. Nine patients and 2 HBD had TPO-Ab (11.2% vs 1%; P < 10-3). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2% vs 1.6%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7%). TSHR-Ab were absent in patients and controls.

CONCLUSION:

This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.

Original language	English
Pages (from-to)	304-309
Number of pages	6
Journal	Laboratory Medicine
Volume	55
Issue number	3
DOIs	https://doi.org/10.1093/labmed/lmad080
Publication status	Published - 1 May 2024

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact [email protected].

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10.1093/labmed/lmad080

Frequency of antithyroid antibodies in patients with primary biliary cholangitisFinal published version, 172 KBLicence: Article 25fa Dutch Copyright Act

Cite this

@article{4dde6ca8523040818ddcfe6be299a2a2,

title = "Frequency of antithyroid antibodies in patients with primary biliary cholangitis",

abstract = "OBJECTIVE: Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti-thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC.METHODS: Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab. RESULTS: Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7\% vs 1.6\%; P < 10-3). Out of 11 patients with ATA, 10 (90.9\%) were female. Nine patients and 2 HBD had TPO-Ab (11.2\% vs 1\%; P < 10-3). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2\% vs 1.6\%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7\%). TSHR-Ab were absent in patients and controls. CONCLUSION: This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.",

author = "Mariam Ghozzi and Amani Mankai and Zeineb Chedly and Ikram Mlika and Wiem Manoubi and Sarra Melayah and Ibtissem Ghedira",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact [email protected].",

year = "2024",

month = may,

day = "1",

doi = "10.1093/labmed/lmad080",

language = "English",

volume = "55",

pages = "304--309",

journal = "Laboratory Medicine",

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TY - JOUR

T1 - Frequency of antithyroid antibodies in patients with primary biliary cholangitis

AU - Ghozzi, Mariam

AU - Mankai, Amani

AU - Chedly, Zeineb

AU - Mlika, Ikram

AU - Manoubi, Wiem

AU - Melayah, Sarra

AU - Ghedira, Ibtissem

N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact [email protected].

PY - 2024/5/1

Y1 - 2024/5/1

N2 - OBJECTIVE: Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti-thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC.METHODS: Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab. RESULTS: Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7% vs 1.6%; P < 10-3). Out of 11 patients with ATA, 10 (90.9%) were female. Nine patients and 2 HBD had TPO-Ab (11.2% vs 1%; P < 10-3). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2% vs 1.6%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7%). TSHR-Ab were absent in patients and controls. CONCLUSION: This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.

AB - OBJECTIVE: Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti-thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC.METHODS: Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab. RESULTS: Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7% vs 1.6%; P < 10-3). Out of 11 patients with ATA, 10 (90.9%) were female. Nine patients and 2 HBD had TPO-Ab (11.2% vs 1%; P < 10-3). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2% vs 1.6%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7%). TSHR-Ab were absent in patients and controls. CONCLUSION: This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.

UR - https://www.scopus.com/pages/publications/85192114266

U2 - 10.1093/labmed/lmad080

DO - 10.1093/labmed/lmad080

M3 - Article

C2 - 37638796

AN - SCOPUS:85192114266

SN - 0007-5027

VL - 55

SP - 304

EP - 309

JO - Laboratory Medicine

JF - Laboratory Medicine

IS - 3

ER -

Frequency of antithyroid antibodies in patients with primary biliary cholangitis

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