FTO genotype is associated with phenotypic variability of body mass index

Jiaqi Yang; RJ Loos; JE Powell; SE Medland; EK Speliotes; DI Chasman; LM Rose; G Thorleifsson; V Steinthorsdottir; R Magi; LL Waite; AV Smith; LM Yerges-Armstrong; KL Monda; D Hadley; A Mahajan; G Li; K Kapur; V Vitart; JE Huffman; SR Wang; C Palmer; T Esko; K Fischer; JH Zhao; Ayse Demirkan; Aaron Isaacs; MF Feitosa; J Luan; NL Heard-Costa; CC White; AU Jackson; M Preuss; A Ziegler; J Eriksson; Z Kutalik; F Frau; IM (Ilja) Nolte; JV van Vliet-Ostaptchouk; JJ (Jouke Jan) Hottenga; KB Jacobs; N (Niek) Verweij; A Goel; Maria Medina Gomez; Karol Estrada Gil; JL Bragg-Gresham; S Sanna; C Sidore; J Tyrer; A Teumer; I Prokopenko; M Mangino; CM Lindgren; TL Assimes; AR Shuldiner; J Hui; JP Beilby; WL McArdle; P Hall; T Hartitunians; L Zgaga; I Kolcic; O Polasek; T Zemunik; Ben Oostra; MJ Junttila; H Gronberg; S Schreiber; A Peters; AA Hicks; J Stephens; NS Foad; J Laitinen; A Pouta; M Kaakinen; G Willemsen; JM Vink; SH Wild; G Navis; FW Asselbergs; G Homuth; U John; C Iribarren; T Harris; L Launer; V Gudnason; JR O'Connell; E Boerwinkel; G Cadby; LJ Palmer; AL James; AW Musk; E Ingelsson; BM Psaty; JS Beckmann; G Waeber; P Vollenweider; C Hayward; AF Wright; I Rudan; LC Groop; A Metspalu; KT Khaw; Cornelia Duijn; I Borecki; MA Province; NJ Wareham; JC Tardif; HV Huikuri; LA Cupples; LD Atwood; CS Fox; M Boehnke; FS Collins; KL Mohlke; J Erdmann; H Schunkert; C Hengstenberg; K Stark; M Lorentzon; C Ohlsson; D Cusi; JA Staessen; MM (Melanie) van der Klauw; PP Pramstaller; S Kathiresan; JD Jolley; S Ripatti; MR Jarvelin; EJC de Geus; DI Boomsma; B Penninx; JF Wilson; H Campbell; SJ Chanock; P van der Harst; A Hamsten; H Watkins; Bert Hofman; JCM Witteman; M.C. Zillikens; André Uitterlinden; Fernando Rivadeneira; LALM Kiemeney; SHHM Vermeulen; GR Abecasis; D Schlessinger; S Schipf; M Stumvoll; A Tonjes; TD Spector; KE North; G Lettre; MI McArthy; SI Berndt; AC Heath; PA Madden; DR Nyholt; GW Montgomery; NG Martin; B McKnight; DP Strachan; WG Hill; H Snieder; PM Ridker; U Thorsteinsdottir; K Stefansson; TM Frayling; JN Hirschhorn; ME Goddard; PM Visscher

doi:10.1038/nature11401

FTO genotype is associated with phenotypic variability of body mass index

Jiaqi Yang, RJ Loos, JE Powell, SE Medland, EK Speliotes, DI Chasman, LM Rose, G Thorleifsson, V Steinthorsdottir, R Magi, LL Waite, AV Smith, LM Yerges-Armstrong, KL Monda, D Hadley, A Mahajan, G Li, K Kapur, V Vitart, JE HuffmanSR Wang, C Palmer, T Esko, K Fischer, JH Zhao, Ayse Demirkan, Aaron Isaacs, MF Feitosa, J Luan, NL Heard-Costa, CC White, AU Jackson, M Preuss, A Ziegler, J Eriksson, Z Kutalik, F Frau, IM (Ilja) Nolte, JV van Vliet-Ostaptchouk, JJ (Jouke Jan) Hottenga, KB Jacobs, N (Niek) Verweij, A Goel, Maria Medina Gomez, Karol Estrada Gil, JL Bragg-Gresham, S Sanna, C Sidore, J Tyrer, A Teumer, I Prokopenko, M Mangino, CM Lindgren, TL Assimes, AR Shuldiner, J Hui, JP Beilby, WL McArdle, P Hall, T Hartitunians, L Zgaga, I Kolcic, O Polasek, T Zemunik, Ben Oostra, MJ Junttila, H Gronberg, S Schreiber, A Peters, AA Hicks, J Stephens, NS Foad, J Laitinen, A Pouta, M Kaakinen, G Willemsen, JM Vink, SH Wild, G Navis, FW Asselbergs, G Homuth, U John, C Iribarren, T Harris, L Launer, V Gudnason, JR O'Connell, E Boerwinkel, G Cadby, LJ Palmer, AL James, AW Musk, E Ingelsson, BM Psaty, JS Beckmann, G Waeber, P Vollenweider, C Hayward, AF Wright, I Rudan, LC Groop, A Metspalu, KT Khaw, Cornelia Duijn, I Borecki, MA Province, NJ Wareham, JC Tardif, HV Huikuri, LA Cupples, LD Atwood, CS Fox, M Boehnke, FS Collins, KL Mohlke, J Erdmann, H Schunkert, C Hengstenberg, K Stark, M Lorentzon, C Ohlsson, D Cusi, JA Staessen, MM (Melanie) van der Klauw, PP Pramstaller, S Kathiresan, JD Jolley, S Ripatti, MR Jarvelin, EJC de Geus, DI Boomsma, B Penninx, JF Wilson, H Campbell, SJ Chanock, P van der Harst, A Hamsten, H Watkins, Bert Hofman, JCM Witteman, M.C. Zillikens, André Uitterlinden, Fernando Rivadeneira, LALM Kiemeney, SHHM Vermeulen, GR Abecasis, D Schlessinger, S Schipf, M Stumvoll, A Tonjes, TD Spector, KE North, G Lettre, MI McArthy, SI Berndt, AC Heath, PA Madden, DR Nyholt, GW Montgomery, NG Martin, B McKnight, DP Strachan, WG Hill, H Snieder, PM Ridker, U Thorsteinsdottir, K Stefansson, TM Frayling, JN Hirschhorn, ME Goddard, PM Visscher

Research output: Contribution to journal › Article › Academic › peer-review

338 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	267-272
Number of pages	6
Journal	Nature
Volume	490
DOIs	https://doi.org/10.1038/nature11401
Publication status	Published - 2012

Research programs

EMC MGC-02-96-01
EMC MM-01-39-09-A
EMC NIHES-01-64-01

Access to Document

10.1038/nature11401

http://hdl.handle.net/1765/56096

Cite this

Yang, J., Loos, RJ., Powell, JE., Medland, SE., Speliotes, EK., Chasman, DI., Rose, LM., Thorleifsson, G., Steinthorsdottir, V., Magi, R., Waite, LL., Smith, AV., Yerges-Armstrong, LM., Monda, KL., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., ... Visscher, PM. (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490, 267-272. https://doi.org/10.1038/nature11401

@article{0e80e7d04f60412d86843ce4b833aa4d,

title = "FTO genotype is associated with phenotypic variability of body mass index",

author = "Jiaqi Yang and RJ Loos and JE Powell and SE Medland and EK Speliotes and DI Chasman and LM Rose and G Thorleifsson and V Steinthorsdottir and R Magi and LL Waite and AV Smith and LM Yerges-Armstrong and KL Monda and D Hadley and A Mahajan and G Li and K Kapur and V Vitart and JE Huffman and SR Wang and C Palmer and T Esko and K Fischer and JH Zhao and Ayse Demirkan and Aaron Isaacs and MF Feitosa and J Luan and NL Heard-Costa and CC White and AU Jackson and M Preuss and A Ziegler and J Eriksson and Z Kutalik and F Frau and Nolte, {IM (Ilja)} and {van Vliet-Ostaptchouk}, JV and Hottenga, {JJ (Jouke Jan)} and KB Jacobs and Verweij, {N (Niek)} and A Goel and {Medina Gomez}, Maria and {Estrada Gil}, Karol and JL Bragg-Gresham and S Sanna and C Sidore and J Tyrer and A Teumer and I Prokopenko and M Mangino and CM Lindgren and TL Assimes and AR Shuldiner and J Hui and JP Beilby and WL McArdle and P Hall and T Hartitunians and L Zgaga and I Kolcic and O Polasek and T Zemunik and Ben Oostra and MJ Junttila and H Gronberg and S Schreiber and A Peters and AA Hicks and J Stephens and NS Foad and J Laitinen and A Pouta and M Kaakinen and G Willemsen and JM Vink and SH Wild and G Navis and FW Asselbergs and G Homuth and U John and C Iribarren and T Harris and L Launer and V Gudnason and JR O'Connell and E Boerwinkel and G Cadby and LJ Palmer and AL James and AW Musk and E Ingelsson and BM Psaty and JS Beckmann and G Waeber and P Vollenweider and C Hayward and AF Wright and I Rudan and LC Groop and A Metspalu and KT Khaw and Cornelia Duijn and I Borecki and MA Province and NJ Wareham and JC Tardif and HV Huikuri and LA Cupples and LD Atwood and CS Fox and M Boehnke and FS Collins and KL Mohlke and J Erdmann and H Schunkert and C Hengstenberg and K Stark and M Lorentzon and C Ohlsson and D Cusi and JA Staessen and {van der Klauw}, {MM (Melanie)} and PP Pramstaller and S Kathiresan and JD Jolley and S Ripatti and MR Jarvelin and {de Geus}, EJC and DI Boomsma and B Penninx and JF Wilson and H Campbell and SJ Chanock and {van der Harst}, P and A Hamsten and H Watkins and Bert Hofman and JCM Witteman and M.C. Zillikens and Andr{\'e} Uitterlinden and Fernando Rivadeneira and LALM Kiemeney and SHHM Vermeulen and GR Abecasis and D Schlessinger and S Schipf and M Stumvoll and A Tonjes and TD Spector and KE North and G Lettre and MI McArthy and SI Berndt and AC Heath and PA Madden and DR Nyholt and GW Montgomery and NG Martin and B McKnight and DP Strachan and WG Hill and H Snieder and PM Ridker and U Thorsteinsdottir and K Stefansson and TM Frayling and JN Hirschhorn and ME Goddard and PM Visscher",

year = "2012",

doi = "10.1038/nature11401",

language = "Undefined/Unknown",

volume = "490",

pages = "267--272",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

}

Yang, J, Loos, RJ, Powell, JE, Medland, SE, Speliotes, EK, Chasman, DI, Rose, LM, Thorleifsson, G, Steinthorsdottir, V, Magi, R, Waite, LL, Smith, AV, Yerges-Armstrong, LM, Monda, KL, Hadley, D, Mahajan, A, Li, G, Kapur, K, Vitart, V, Huffman, JE, Wang, SR, Palmer, C, Esko, T, Fischer, K, Zhao, JH, Demirkan, A, Isaacs, A, Feitosa, MF, Luan, J, Heard-Costa, NL, White, CC, Jackson, AU, Preuss, M, Ziegler, A, Eriksson, J, Kutalik, Z, Frau, F, Nolte, IM, van Vliet-Ostaptchouk, JV, Hottenga, JJ, Jacobs, KB, Verweij, N, Goel, A, Medina Gomez, M, Estrada Gil, K, Bragg-Gresham, JL, Sanna, S, Sidore, C, Tyrer, J, Teumer, A, Prokopenko, I, Mangino, M, Lindgren, CM, Assimes, TL, Shuldiner, AR, Hui, J, Beilby, JP, McArdle, WL, Hall, P, Hartitunians, T, Zgaga, L, Kolcic, I, Polasek, O, Zemunik, T, Oostra, B, Junttila, MJ, Gronberg, H, Schreiber, S, Peters, A, Hicks, AA, Stephens, J, Foad, NS, Laitinen, J, Pouta, A, Kaakinen, M, Willemsen, G, Vink, JM, Wild, SH, Navis, G, Asselbergs, FW, Homuth, G, John, U, Iribarren, C, Harris, T, Launer, L, Gudnason, V, O'Connell, JR, Boerwinkel, E, Cadby, G, Palmer, LJ, James, AL, Musk, AW, Ingelsson, E, Psaty, BM, Beckmann, JS, Waeber, G, Vollenweider, P, Hayward, C, Wright, AF, Rudan, I, Groop, LC, Metspalu, A, Khaw, KT, Duijn, C, Borecki, I, Province, MA, Wareham, NJ, Tardif, JC, Huikuri, HV, Cupples, LA, Atwood, LD, Fox, CS, Boehnke, M, Collins, FS, Mohlke, KL, Erdmann, J, Schunkert, H, Hengstenberg, C, Stark, K, Lorentzon, M, Ohlsson, C, Cusi, D, Staessen, JA, van der Klauw, MM, Pramstaller, PP, Kathiresan, S, Jolley, JD, Ripatti, S, Jarvelin, MR, de Geus, EJC, Boomsma, DI, Penninx, B, Wilson, JF, Campbell, H, Chanock, SJ, van der Harst, P, Hamsten, A, Watkins, H, Hofman, B, Witteman, JCM, Zillikens, MC, Uitterlinden, A , Rivadeneira, F, Kiemeney, LALM, Vermeulen, SHHM, Abecasis, GR, Schlessinger, D, Schipf, S, Stumvoll, M, Tonjes, A, Spector, TD, North, KE, Lettre, G, McArthy, MI, Berndt, SI, Heath, AC, Madden, PA, Nyholt, DR, Montgomery, GW, Martin, NG, McKnight, B, Strachan, DP, Hill, WG, Snieder, H, Ridker, PM, Thorsteinsdottir, U, Stefansson, K, Frayling, TM, Hirschhorn, JN, Goddard, ME & Visscher, PM 2012, 'FTO genotype is associated with phenotypic variability of body mass index', Nature, vol. 490, pp. 267-272. https://doi.org/10.1038/nature11401

TY - JOUR

T1 - FTO genotype is associated with phenotypic variability of body mass index

AU - Yang, Jiaqi

AU - Loos, RJ

AU - Powell, JE

AU - Medland, SE

AU - Speliotes, EK

AU - Chasman, DI

AU - Rose, LM

AU - Thorleifsson, G

AU - Steinthorsdottir, V

AU - Magi, R

AU - Waite, LL

AU - Smith, AV

AU - Yerges-Armstrong, LM

AU - Monda, KL

AU - Hadley, D

AU - Mahajan, A

AU - Li, G

AU - Kapur, K

AU - Vitart, V

AU - Huffman, JE

AU - Wang, SR

AU - Palmer, C

AU - Esko, T

AU - Fischer, K

AU - Zhao, JH

AU - Demirkan, Ayse

AU - Isaacs, Aaron

AU - Feitosa, MF

AU - Luan, J

AU - Heard-Costa, NL

AU - White, CC

AU - Jackson, AU

AU - Preuss, M

AU - Ziegler, A

AU - Eriksson, J

AU - Kutalik, Z

AU - Frau, F

AU - Nolte, IM (Ilja)

AU - van Vliet-Ostaptchouk, JV

AU - Hottenga, JJ (Jouke Jan)

AU - Jacobs, KB

AU - Verweij, N (Niek)

AU - Goel, A

AU - Medina Gomez, Maria

AU - Estrada Gil, Karol

AU - Bragg-Gresham, JL

AU - Sanna, S

AU - Sidore, C

AU - Tyrer, J

AU - Teumer, A

AU - Prokopenko, I

AU - Mangino, M

AU - Lindgren, CM

AU - Assimes, TL

AU - Shuldiner, AR

AU - Hui, J

AU - Beilby, JP

AU - McArdle, WL

AU - Hall, P

AU - Hartitunians, T

AU - Zgaga, L

AU - Kolcic, I

AU - Polasek, O

AU - Zemunik, T

AU - Oostra, Ben

AU - Junttila, MJ

AU - Gronberg, H

AU - Schreiber, S

AU - Peters, A

AU - Hicks, AA

AU - Stephens, J

AU - Foad, NS

AU - Laitinen, J

AU - Pouta, A

AU - Kaakinen, M

AU - Willemsen, G

AU - Vink, JM

AU - Wild, SH

AU - Navis, G

AU - Asselbergs, FW

AU - Homuth, G

AU - John, U

AU - Iribarren, C

AU - Harris, T

AU - Launer, L

AU - Gudnason, V

AU - O'Connell, JR

AU - Boerwinkel, E

AU - Cadby, G

AU - Palmer, LJ

AU - James, AL

AU - Musk, AW

AU - Ingelsson, E

AU - Psaty, BM

AU - Beckmann, JS

AU - Waeber, G

AU - Vollenweider, P

AU - Hayward, C

AU - Wright, AF

AU - Rudan, I

AU - Groop, LC

AU - Metspalu, A

AU - Khaw, KT

AU - Duijn, Cornelia

AU - Borecki, I

AU - Province, MA

AU - Wareham, NJ

AU - Tardif, JC

AU - Huikuri, HV

AU - Cupples, LA

AU - Atwood, LD

AU - Fox, CS

AU - Boehnke, M

AU - Collins, FS

AU - Mohlke, KL

AU - Erdmann, J

AU - Schunkert, H

AU - Hengstenberg, C

AU - Stark, K

AU - Lorentzon, M

AU - Ohlsson, C

AU - Cusi, D

AU - Staessen, JA

AU - van der Klauw, MM (Melanie)

AU - Pramstaller, PP

AU - Kathiresan, S

AU - Jolley, JD

AU - Ripatti, S

AU - Jarvelin, MR

AU - de Geus, EJC

AU - Boomsma, DI

AU - Penninx, B

AU - Wilson, JF

AU - Campbell, H

AU - Chanock, SJ

AU - van der Harst, P

AU - Hamsten, A

AU - Watkins, H

AU - Hofman, Bert

AU - Witteman, JCM

AU - Zillikens, M.C.

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - Kiemeney, LALM

AU - Vermeulen, SHHM

AU - Abecasis, GR

AU - Schlessinger, D

AU - Schipf, S

AU - Stumvoll, M

AU - Tonjes, A

AU - Spector, TD

AU - North, KE

AU - Lettre, G

AU - McArthy, MI

AU - Berndt, SI

AU - Heath, AC

AU - Madden, PA

AU - Nyholt, DR

AU - Montgomery, GW

AU - Martin, NG

AU - McKnight, B

AU - Strachan, DP

AU - Hill, WG

AU - Snieder, H

AU - Ridker, PM

AU - Thorsteinsdottir, U

AU - Stefansson, K

AU - Frayling, TM

AU - Hirschhorn, JN

AU - Goddard, ME

AU - Visscher, PM

PY - 2012

Y1 - 2012

U2 - 10.1038/nature11401

DO - 10.1038/nature11401

M3 - Article

C2 - 22982992

SN - 0028-0836

VL - 490

SP - 267

EP - 272

JO - Nature

JF - Nature

ER -