Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association

RSRM Martherus, Wim Sluiter, EDJ Timmer, SJV VanHerle, HJM Smeets, TAY Ayoubi

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32 Citations (Scopus)


Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments using gene-knockdown we could indeed confirm this and furthermore we asserted CHCHD 10 to play a role in complex IV activity. (C) 2010 Published by Elsevier Inc.
Original languageUndefined/Unknown
Pages (from-to)203-208
Number of pages6
JournalBiochemical & Biophysical Research Communications
Issue number2
Publication statusPublished - 2010

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