Functional outcomes after radiotherapy or laser surgery in early glottic carcinoma: A systematic review

Yda Loon, EV Sjogren, TPM Langeveld, R.J. Baatenburg de Jong, JW Schoones, MA van Rossum

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Abstract

Background Early glottic carcinoma is treated with laser surgery or radiotherapy, but which treatment has better functional outcomes is unclear. This systematic review compared functional outcomes (voice, swallowing, quality of life [QOL]) in more extended T1a and limited T2 tumors (1) between treatments and (2) between greater and lesser laser resections. Methods A systematic literature search covered relevant databases from 1990 to 2009, combining all patient/problem, intervention, comparison, outcome (PICO) keyword variations. Results A total of 19 papers met the inclusion criteria, all of which were level IV evidence. Papers reported only voice and QOL. Heterogeneity of outcome measures prevented data pooling. Uncertainty about tumor comparability (depth, extent) between the 2 treatments, small subject numbers, and poor-quality reporting hindered interpretation. Conclusions To allow comparison of laser surgery versus radiotherapy, a standardized method is needed that accurately measures tumor extent and depth. Agreement on functional outcome measures is necessary to allow comparison of treatments and resection types. Multicenter studies should be encouraged to guarantee adequate subject numbers. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012
Original languageUndefined/Unknown
Pages (from-to)1179-1189
Number of pages11
JournalHead & Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume34
Issue number8
DOIs
Publication statusPublished - 2012

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