Functional reactivity of 5-HT receptors in human umbilicalcord and maternal subcutaneous fat arteries afternormotensive or pre-eclamptic pregnancy

Saurabh Gupta, Lidwien Hanff, Willy Visser, Eric Steegers, Pramod Saxena, Arnold Vulto, Antoinette Maassen van den Brink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review



To investigate the functional reactivity of
5-hydroxytryptamine (serotonin; 5-HT) receptors in foetal
umbilical cord arteries (UCA) and maternal subcutaneous
fat resistance arteries (SFA) in normotensive and preeclamptic pregnancy.


Study groups were divided based on the presence
or absence of pre-eclampsia and the duration of gestation.
Methods Segments of UCA and SFA were mounted in
tissue baths and concentration–response curves to 5-HT
and sumatriptan (5-HT1B/1D receptor agonist) were
constructed in the absence or presence of ketanserin
(5-HT2A receptor antagonist) or GR125743 (5-HT1B/1D
receptor antagonist).


Both 5-HT and sumatriptan contracted all UCA
segments studied. The responses to 5-HT and the potency
of ketanserin in UCA were not different between the study
groups, indicating a similar profile of the 5-HT2A receptor. In
contrast, the potencies of sumatriptan and GR125743 were
significantly higher in normotensive full-term pregnancies
than in normotensive pre-term pregnancies in UCA. The
response to sumatriptan in UCA arteries was not
significantly different between pre-eclamptic and
normotensive pregnancies. However, the potency of both
sumatriptan and GR125743 was positively correlated to the
gestational age in the normotensive group, whereas this
relationship was absent in the pre-eclamptic group. In SFA,
responses to 5-HT and sumatriptan were not different
between the pre-eclamptic patients and normotensive


In both UCA and SFA, 5-HT1B/1D and 5-HT2A
receptors mediate vasoconstriction. The sensitivity of
5-HT1B/1D receptors increases in the last trimester in
the UCA in normal pregnancies, which seems to be
expedited in pre-eclamptic patients. Further studies
on 5-HT1B/ID receptors will thus give new insights into the
foetal development and pathophysiology of pre-eclampsia.
J Hypertens 24:1345–1353 Q 2006 Lippincott Williams &
Original languageEnglish
Pages (from-to)1345–1353
JournalJournal of Hypertension
Early online date28 Feb 2006
Publication statusPublished - 2006


Dive into the research topics of 'Functional reactivity of 5-HT receptors in human umbilicalcord and maternal subcutaneous fat arteries afternormotensive or pre-eclamptic pregnancy'. Together they form a unique fingerprint.

Cite this