Abstract
Objective:
To investigate the functional reactivity of
5-hydroxytryptamine (serotonin; 5-HT) receptors in foetal
umbilical cord arteries (UCA) and maternal subcutaneous
fat resistance arteries (SFA) in normotensive and preeclamptic pregnancy.
Design:
Study groups were divided based on the presence
or absence of pre-eclampsia and the duration of gestation.
Methods Segments of UCA and SFA were mounted in
tissue baths and concentration–response curves to 5-HT
and sumatriptan (5-HT1B/1D receptor agonist) were
constructed in the absence or presence of ketanserin
(5-HT2A receptor antagonist) or GR125743 (5-HT1B/1D
receptor antagonist).
Results:
Both 5-HT and sumatriptan contracted all UCA
segments studied. The responses to 5-HT and the potency
of ketanserin in UCA were not different between the study
groups, indicating a similar profile of the 5-HT2A receptor. In
contrast, the potencies of sumatriptan and GR125743 were
significantly higher in normotensive full-term pregnancies
than in normotensive pre-term pregnancies in UCA. The
response to sumatriptan in UCA arteries was not
significantly different between pre-eclamptic and
normotensive pregnancies. However, the potency of both
sumatriptan and GR125743 was positively correlated to the
gestational age in the normotensive group, whereas this
relationship was absent in the pre-eclamptic group. In SFA,
responses to 5-HT and sumatriptan were not different
between the pre-eclamptic patients and normotensive
controls.
Conclusions:
In both UCA and SFA, 5-HT1B/1D and 5-HT2A
receptors mediate vasoconstriction. The sensitivity of
5-HT1B/1D receptors increases in the last trimester in
the UCA in normal pregnancies, which seems to be
expedited in pre-eclamptic patients. Further studies
on 5-HT1B/ID receptors will thus give new insights into the
foetal development and pathophysiology of pre-eclampsia.
J Hypertens 24:1345–1353 Q 2006 Lippincott Williams &
Wilkins.
To investigate the functional reactivity of
5-hydroxytryptamine (serotonin; 5-HT) receptors in foetal
umbilical cord arteries (UCA) and maternal subcutaneous
fat resistance arteries (SFA) in normotensive and preeclamptic pregnancy.
Design:
Study groups were divided based on the presence
or absence of pre-eclampsia and the duration of gestation.
Methods Segments of UCA and SFA were mounted in
tissue baths and concentration–response curves to 5-HT
and sumatriptan (5-HT1B/1D receptor agonist) were
constructed in the absence or presence of ketanserin
(5-HT2A receptor antagonist) or GR125743 (5-HT1B/1D
receptor antagonist).
Results:
Both 5-HT and sumatriptan contracted all UCA
segments studied. The responses to 5-HT and the potency
of ketanserin in UCA were not different between the study
groups, indicating a similar profile of the 5-HT2A receptor. In
contrast, the potencies of sumatriptan and GR125743 were
significantly higher in normotensive full-term pregnancies
than in normotensive pre-term pregnancies in UCA. The
response to sumatriptan in UCA arteries was not
significantly different between pre-eclamptic and
normotensive pregnancies. However, the potency of both
sumatriptan and GR125743 was positively correlated to the
gestational age in the normotensive group, whereas this
relationship was absent in the pre-eclamptic group. In SFA,
responses to 5-HT and sumatriptan were not different
between the pre-eclamptic patients and normotensive
controls.
Conclusions:
In both UCA and SFA, 5-HT1B/1D and 5-HT2A
receptors mediate vasoconstriction. The sensitivity of
5-HT1B/1D receptors increases in the last trimester in
the UCA in normal pregnancies, which seems to be
expedited in pre-eclamptic patients. Further studies
on 5-HT1B/ID receptors will thus give new insights into the
foetal development and pathophysiology of pre-eclampsia.
J Hypertens 24:1345–1353 Q 2006 Lippincott Williams &
Wilkins.
| Original language | English |
|---|---|
| Pages (from-to) | 1345–1353 |
| Journal | Journal of Hypertension |
| Volume | 24 |
| Early online date | 28 Feb 2006 |
| Publication status | Published - 2006 |