Fungal strategies for overcoming host innate immune response

LYA Chai, MG Netea, Alieke Vonk, BJ Kullberg

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Abstract

A successful pathogen is one that is able to effectively survive and evade detection by the host innate immune defense. Fungal pathogens have adopted strategies which evade host defense and eventually cause disease in at-risk patients. Shielding of stimulatory surface recognition molecules, shedding of decoy components, induction of anti-inflammatory signals, complement evasion and resilient survival capacity are successful evasion mechanisms employed by fungal pathogens. Understanding these complex pathways of immune evasion can potentially contribute to development of novel therapeutic strategies against fungal infections.
Original languageUndefined/Unknown
Pages (from-to)227-236
Number of pages10
JournalMedical Mycology
Volume47
Issue number3
DOIs
Publication statusPublished - 2009

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