Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field

V.A.S.H. Dalm; Leo Hofland; S.W.J. Lamberts

doi:10.1016/j.mce.2007.09.005

Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field

V.A.S.H. Dalm, Leo Hofland, S.W.J. Lamberts

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Somatostatin receptors (sst), somatostatin (SS) and cortistatin (CST) are widely expressed in the various systems in the human and rodent organisms and are "responsible" for maintaining homeostasis, which is essential for survival. Because of their broad expression pattern sst, SS and CST interactions may play regulatory roles in both physiology and pathophysiology in mammalian organisms. SS analogue treatment strategies as well as the use of SS analogues for diagnostic purposes have been established in diseases of different origins. This review focuses on the currently determined role for SS analogues in today's clinical practice and the potential clinical prospects for SS, CST and sst interactions in the future, with a focus on neuroendocrine and non-neuroendocrine tumours and immune-mediated diseases. Moreover, the role of new SS analogues and new insights in sst physiology will be discussed. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	262-277
Number of pages	16
Journal	Molecular and Cellular Endocrinology
Volume	286
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2007.09.005
Publication status	Published - 2008

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EMC MM-01-39-01

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mce.2007.09.005

http://hdl.handle.net/1765/29666

Cite this

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title = "Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field",

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T1 - Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field

AU - Dalm, V.A.S.H.

AU - Hofland, Leo

AU - Lamberts, S.W.J.

PY - 2008

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AB - Somatostatin receptors (sst), somatostatin (SS) and cortistatin (CST) are widely expressed in the various systems in the human and rodent organisms and are "responsible" for maintaining homeostasis, which is essential for survival. Because of their broad expression pattern sst, SS and CST interactions may play regulatory roles in both physiology and pathophysiology in mammalian organisms. SS analogue treatment strategies as well as the use of SS analogues for diagnostic purposes have been established in diseases of different origins. This review focuses on the currently determined role for SS analogues in today's clinical practice and the potential clinical prospects for SS, CST and sst interactions in the future, with a focus on neuroendocrine and non-neuroendocrine tumours and immune-mediated diseases. Moreover, the role of new SS analogues and new insights in sst physiology will be discussed. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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DO - 10.1016/j.mce.2007.09.005

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