Gain-of-function experiments on H7N9

Ron A M Fouchier; Yoshihiro Kawaoka; Carol Cardona; Richard W Compans; Adolfo García-Sastre; Elena A Govorkova; Yi Guan; Sander Herfst; Walter A Orenstein; J S Malik Peiris; Daniel R Perez; Juergen A Richt; Charles Russell; Stacey L Schultz-Cherry; Derek J Smith; John Steel; S Mark Tompkins; David J Topham; John J Treanor; Ralph A Tripp; Richard J Webby; Robert G Webster

doi:10.1038/500150a

Gain-of-function experiments on H7N9

Ron A M Fouchier^*, Yoshihiro Kawaoka^*, Carol Cardona, Richard W Compans, Adolfo García-Sastre, Elena A Govorkova, Yi Guan, Sander Herfst, Walter A Orenstein, J S Malik Peiris, Daniel R Perez, Juergen A Richt, Charles Russell, Stacey L Schultz-Cherry, Derek J Smith, John Steel, S Mark Tompkins, David J Topham, John J Treanor, Ralph A TrippRichard J Webby, Robert G Webster

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.

To better assess the pandemic threat posed by A(H7N9) viruses, investigators from the NIAID Centers of Excellence in Influenza Research and Surveillance and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for further research, including experiments that may be classified as 'gain of function' (GOF).

Here we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.
[...]

Original language	English
Pages (from-to)	150-1
Number of pages	2
Journal	Nature
Volume	500
Issue number	7461
DOIs	https://doi.org/10.1038/500150a
Publication status	Published - 8 Aug 2013

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10.1038/500150a

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Fouchier, R. A. M., Kawaoka, Y., Cardona, C., Compans, R. W., García-Sastre, A., Govorkova, E. A., Guan, Y., Herfst, S., Orenstein, W. A., Peiris, J. S. M., Perez, D. R., Richt, J. A., Russell, C., Schultz-Cherry, S. L., Smith, D. J., Steel, J., Tompkins, S. M., Topham, D. J., Treanor, J. J., ... Webster, R. G. (2013). Gain-of-function experiments on H7N9. Nature, 500(7461), 150-1. https://doi.org/10.1038/500150a

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title = "Gain-of-function experiments on H7N9",

abstract = "Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.To better assess the pandemic threat posed by A(H7N9) viruses, investigators from the NIAID Centers of Excellence in Influenza Research and Surveillance and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for further research, including experiments that may be classified as 'gain of function' (GOF).Here we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.[...]",

author = "Fouchier, {Ron A M} and Yoshihiro Kawaoka and Carol Cardona and Compans, {Richard W} and Adolfo Garc{\'i}a-Sastre and Govorkova, {Elena A} and Yi Guan and Sander Herfst and Orenstein, {Walter A} and Peiris, {J S Malik} and Perez, {Daniel R} and Richt, {Juergen A} and Charles Russell and Schultz-Cherry, {Stacey L} and Smith, {Derek J} and John Steel and Tompkins, {S Mark} and Topham, {David J} and Treanor, {John J} and Tripp, {Ralph A} and Webby, {Richard J} and Webster, {Robert G}",

year = "2013",

month = aug,

day = "8",

doi = "10.1038/500150a",

language = "English",

volume = "500",

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issn = "0028-0836",

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Fouchier, RAM, Kawaoka, Y, Cardona, C, Compans, RW, García-Sastre, A, Govorkova, EA, Guan, Y, Herfst, S, Orenstein, WA, Peiris, JSM, Perez, DR, Richt, JA, Russell, C, Schultz-Cherry, SL, Smith, DJ, Steel, J, Tompkins, SM, Topham, DJ, Treanor, JJ, Tripp, RA, Webby, RJ & Webster, RG 2013, 'Gain-of-function experiments on H7N9', Nature, vol. 500, no. 7461, pp. 150-1. https://doi.org/10.1038/500150a

TY - JOUR

T1 - Gain-of-function experiments on H7N9

AU - Fouchier, Ron A M

AU - Kawaoka, Yoshihiro

AU - Cardona, Carol

AU - Compans, Richard W

AU - García-Sastre, Adolfo

AU - Govorkova, Elena A

AU - Guan, Yi

AU - Herfst, Sander

AU - Orenstein, Walter A

AU - Peiris, J S Malik

AU - Perez, Daniel R

AU - Richt, Juergen A

AU - Russell, Charles

AU - Schultz-Cherry, Stacey L

AU - Smith, Derek J

AU - Steel, John

AU - Tompkins, S Mark

AU - Topham, David J

AU - Treanor, John J

AU - Tripp, Ralph A

AU - Webby, Richard J

AU - Webster, Robert G

PY - 2013/8/8

Y1 - 2013/8/8

N2 - Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.To better assess the pandemic threat posed by A(H7N9) viruses, investigators from the NIAID Centers of Excellence in Influenza Research and Surveillance and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for further research, including experiments that may be classified as 'gain of function' (GOF).Here we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.[...]

AB - Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.To better assess the pandemic threat posed by A(H7N9) viruses, investigators from the NIAID Centers of Excellence in Influenza Research and Surveillance and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for further research, including experiments that may be classified as 'gain of function' (GOF).Here we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.[...]

U2 - 10.1038/500150a

DO - 10.1038/500150a

M3 - Comment/Letter to the editor

C2 - 23925229

SN - 0028-0836

VL - 500

SP - 150

EP - 151

JO - Nature

JF - Nature

IS - 7461

ER -

Gain-of-function experiments on H7N9

Abstract

Bibliographical note

UN SDGs

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