Gain-of-function Na(v)1.8 mutations in painful neuropathy

CG Faber, G Lauria, ISJ (Ingemar) Merkies, XY Cheng, CY Han, HS Ahn, AK Persson, JGJ (Janneke) Hoeijmakers, MM Gerrits, T Pierro, R Lombardi, D Kapetis, SD Dib-Hajj, SG Waxman

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Abstract

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-function variants of sodium channel Na(v)1.7 have recently been found in similar to 30% of cases of idiopathic painful small-fiber neuropathy. Here, we describe mutations in Na(v)1.8, another sodium channel that is specifically expressed in dorsal root ganglion (DRG) neurons and peripheral nerve axons, in patients with painful neuropathy. Seven Na(v)1.8 mutations were identified in 9 subjects within a series of 104 patients with painful predominantly small-fiber neuropathy. Three mutations met criteria for potential pathogenicity based on predictive algorithms and were assessed by voltage and current clamp. Functional profiling showed that two of these three Na(v)1.8 mutations enhance the channel's response to depolarization and produce hyperexcitability in DRG neurons. These observations suggest that mutations of Na(v)1.8 contribute to painful peripheral neuropathy.
Original languageUndefined/Unknown
Pages (from-to)19444-19449
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of Ame
Volume109
Issue number47
DOIs
Publication statusPublished - 2012

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