Gastric H+/K+-atpase

Corné H.W. Klaassen, Jan Joep H.H.M. De Pont*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)


The gastric H+/K+-ATPase is an enzyme located in the tubulovesicular system and the apical membrane of the parietal cell and plays a crucial role in the process of gastric acid secretion. The enzyme catalyses an electroneutral exchange of H+ versus K+ It consists of a catalytic α-subunit and a heavily glycosylated β-subunit, both of which are rather homologous to their counterparts in Na+/K+-ATPase. In this review, molecular and genetic aspects of this enzyme are reviewed with reference to similar enzymes in other tissues.

Original languageEnglish
Pages (from-to)115-134
Number of pages20
JournalCellular Physiology and Biochemistry
Issue number3-4
Publication statusPublished - 1994
Externally publishedYes

Bibliographical note

© 1994 S. Karger AG, Basel


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