Gastric H+/K+-atpase

Corné H.W. Klaassen; Jan Joep H.H.M. De Pont

doi:10.1159/000154716

Gastric H⁺/K⁺-atpase

Corné H.W. Klaassen
, Jan Joep H.H.M. De Pont^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

The gastric H⁺/K⁺-ATPase is an enzyme located in the tubulovesicular system and the apical membrane of the parietal cell and plays a crucial role in the process of gastric acid secretion. The enzyme catalyses an electroneutral exchange of H⁺ versus K⁺ It consists of a catalytic α-subunit and a heavily glycosylated β-subunit, both of which are rather homologous to their counterparts in Na⁺/K⁺-ATPase. In this review, molecular and genetic aspects of this enzyme are reviewed with reference to similar enzymes in other tissues.

Original language	English
Pages (from-to)	115-134
Number of pages	20
Journal	Cellular Physiology and Biochemistry
Volume	4
Issue number	3-4
DOIs	https://doi.org/10.1159/000154716
Publication status	Published - 1994
Externally published	Yes

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title = "Gastric H+/K+-atpase",

abstract = "The gastric H+/K+-ATPase is an enzyme located in the tubulovesicular system and the apical membrane of the parietal cell and plays a crucial role in the process of gastric acid secretion. The enzyme catalyses an electroneutral exchange of H+ versus K+ It consists of a catalytic α-subunit and a heavily glycosylated β-subunit, both of which are rather homologous to their counterparts in Na+/K+-ATPase. In this review, molecular and genetic aspects of this enzyme are reviewed with reference to similar enzymes in other tissues.",

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AB - The gastric H+/K+-ATPase is an enzyme located in the tubulovesicular system and the apical membrane of the parietal cell and plays a crucial role in the process of gastric acid secretion. The enzyme catalyses an electroneutral exchange of H+ versus K+ It consists of a catalytic α-subunit and a heavily glycosylated β-subunit, both of which are rather homologous to their counterparts in Na+/K+-ATPase. In this review, molecular and genetic aspects of this enzyme are reviewed with reference to similar enzymes in other tissues.

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DO - 10.1159/000154716

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JO - Cellular Physiology and Biochemistry

JF - Cellular Physiology and Biochemistry

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ER -

Gastric H⁺/K⁺-atpase

Abstract

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