Gastric MALT lymphoma: Epidemiology and high adenocarcinoma risk in a nation-wide study

Lisette Capelle, Annemarie de Vries, Caspar Looman, MK Casparie, H Boot, GA Meijer, Ernst Kuipers

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Abstract

Background: Gastric marginal zone non-Hodgkin lymphomas MALT type (gMALT) and gastric adenocarcinomas (GC) are long-term complications of chronic Helicobacter pylori gastritis, however, the incidence of gMALT and the GC risk in these patients is unclear. Objective: To evaluate epidemiological time trends of gMALT in the Netherlands and to estimate GC risk. Methods: Patients with a first diagnosis of gMALT between 1991 and 2006 were identified in the Dutch nation-wide histopathology registry (PALGA). Age-standardised incidence rates were calculated. The incidences of GC in patients with gMALT and in the Dutch population were compared. Relative risks were calculated by a Poisson Model. Results: In total, 1419 patients were newly diagnosed with gMALT, compatible with an incidence of 0.41/100,000/year. GC was diagnosed in 34 (2.4%) patients of the cohort. Patients with gMALT had a sixfold increased risk for GC in comparison with the general population (p < 0.001). This risk was 16.6 times higher in gMALT patients aged between 45 and 59 years than in the Dutch population (p < 0.001). Conclusions: GC risk in patients with gMALT is six times higher than in the Dutch population and war-rants accurate re-evaluation after diagnosis and treatment for gMALT. (C) 2008 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)2470-2476
Number of pages7
JournalEuropean Journal of Cancer
Volume44
Issue number16
DOIs
Publication statusPublished - 2008

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