Gastric microbiota beyond h. Pylori: An emerging critical character in gastric carcinogenesis

Jun Wen; Harry Cheuk Hay Lau; Maikel Peppelenbosch; Jun Yu

doi:10.3390/biomedicines9111680

Gastric microbiota beyond h. Pylori: An emerging critical character in gastric carcinogenesis

Jun Wen, Harry Cheuk Hay Lau, Maikel Peppelenbosch, Jun Yu^*

^*Corresponding author for this work

Gastroenterology & Hepatology

Research output: Contribution to journal › Review article › Academic › peer-review

16 Citations (Scopus)

29 Downloads (Pure)

Abstract

Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than H. pylori in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-H. pylori gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.

Original language	English
Article number	1680
Journal	Biomedicines
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/biomedicines9111680
Publication status	Published - Nov 2021

Bibliographical note

Funding Information:
Funding: This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor’s Discretionary Fund Chinese University of Hong Kong.

Funding Information:
This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor?s Discretionary Fund Chinese University of Hong Kong.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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Gastric Microbiota beyond H. pyloriFinal published version, 693 KBLicence: CC BY

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title = "Gastric microbiota beyond h. Pylori: An emerging critical character in gastric carcinogenesis",

abstract = "Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than H. pylori in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-H. pylori gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.",

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note = "Funding Information: Funding: This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor{\textquoteright}s Discretionary Fund Chinese University of Hong Kong. Funding Information: This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor?s Discretionary Fund Chinese University of Hong Kong. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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N1 - Funding Information: Funding: This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor’s Discretionary Fund Chinese University of Hong Kong. Funding Information: This study was supported by the National Key R&D Program of China (No. 2020YFA0509200 /2020YFA0509203), RGC Theme-based Res Scheme Hong Kong (T21-705/20-N), RGC Collaborative Research Fund (C4039-19GF and C7065-18GF), RGC-GRF Hong Kong (14163817), and Vice-Chancellor?s Discretionary Fund Chinese University of Hong Kong. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than H. pylori in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-H. pylori gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.

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Gastric microbiota beyond h. Pylori: An emerging critical character in gastric carcinogenesis

Abstract

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