Gender aspects of CGRP in migraine

Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Carlos M. Villalón, Antoinette MaassenVanDenBrink*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

80 Citations (Scopus)
2 Downloads (Pure)



Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. 


To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. 


Gender differences are evident in migraine. Several studies indicate that fluctuations of ovarian steroid hormone (mainly estrogen) levels modulate CGRP in the trigeminovascular system during different reproductive milestones. Such interactions need to be considered when conducting future animal and human experiments, since these differences may contribute to the development of gender-specific therapies.

Original languageEnglish
Pages (from-to)435-444
Number of pages10
Issue number3
Publication statusE-pub ahead of print - 30 Oct 2017

Bibliographical note

Publisher Copyright:
© International Headache Society 2017.


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