Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group

Maria Gloria Rossetti; Praveetha Patalay; Scott Mackey; Nicholas B Allen; Albert Batalla; Marcella Bellani; Yann Chye; Janna Cousijn; Anna E Goudriaan; Robert Hester; Kent Hutchison; Chiang-Shan R Li; Rocio Martin-Santos; Reza Momenan; Rajita Sinha; Lianne Schmaal; Zsuzsika Sjoerds; Nadia Solowij; Chao Suo; Ruth J van Holst; Dick J Veltman; Murat Yücel; Paul M Thompson; Patricia Conrod; Hugh Garavan; Paolo Brambilla; Valentina Lorenzetti

doi:10.1016/j.nicl.2021.102636

Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group

Maria Gloria Rossetti, Praveetha Patalay, Scott Mackey, Nicholas B Allen, Albert Batalla, Marcella Bellani, Yann Chye, Janna Cousijn, Anna E Goudriaan, Robert Hester, Kent Hutchison, Chiang-Shan R Li, Rocio Martin-Santos, Reza Momenan, Rajita Sinha, Lianne Schmaal, Zsuzsika Sjoerds, Nadia Solowij, Chao Suo, Ruth J van HolstDick J Veltman, Murat Yücel, Paul M Thompson, Patricia Conrod, Hugh Garavan, Paolo Brambilla, Valentina Lorenzetti

Clinical Psychology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.

Original language	English
Article number	102636
Journal	NeuroImage: Clinical
Volume	30
DOIs	https://doi.org/10.1016/j.nicl.2021.102636
Publication status	Published - 1 Jan 2021

Bibliographical note

Funding Information:
Data collection: Drs. Sjoerds and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Sinha received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Yücel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. Dr Lorenzetti was supported by The Australian Catholic University through a competitive scheme.

Funding Information:
P.T. received partial grant support from Biogen, Inc. (Boston, USA) for research unrelated to this manuscript. M.Y. has received funding from several law firms in relation to expert witness reports.

Publisher Copyright:
© 2021

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Gender-related neuroanatomical differences in alcohol dependenceFinal published version, 1.21 MBLicence: CC BY-NC-ND

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Rossetti, M. G., Patalay, P., Mackey, S., Allen, N. B., Batalla, A., Bellani, M., Chye, Y., Cousijn, J., Goudriaan, A. E., Hester, R., Hutchison, K., Li, C.-S. R., Martin-Santos, R., Momenan, R., Sinha, R., Schmaal, L., Sjoerds, Z., Solowij, N., Suo, C., ... Lorenzetti, V. (2021). Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group. NeuroImage: Clinical, 30, Article 102636. https://doi.org/10.1016/j.nicl.2021.102636

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title = "Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group",

abstract = "Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.",

author = "Rossetti, {Maria Gloria} and Praveetha Patalay and Scott Mackey and Allen, {Nicholas B} and Albert Batalla and Marcella Bellani and Yann Chye and Janna Cousijn and Goudriaan, {Anna E} and Robert Hester and Kent Hutchison and Li, {Chiang-Shan R} and Rocio Martin-Santos and Reza Momenan and Rajita Sinha and Lianne Schmaal and Zsuzsika Sjoerds and Nadia Solowij and Chao Suo and {van Holst}, {Ruth J} and Veltman, {Dick J} and Murat Y{\"u}cel and Thompson, {Paul M} and Patricia Conrod and Hugh Garavan and Paolo Brambilla and Valentina Lorenzetti",

note = "Funding Information: Data collection: Drs. Sjoerds and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Sinha received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Y{\"u}cel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. Dr Lorenzetti was supported by The Australian Catholic University through a competitive scheme. Funding Information: P.T. received partial grant support from Biogen, Inc. (Boston, USA) for research unrelated to this manuscript. M.Y. has received funding from several law firms in relation to expert witness reports. Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/j.nicl.2021.102636",

language = "English",

volume = "30",

journal = "NeuroImage: Clinical",

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Rossetti, MG, Patalay, P, Mackey, S, Allen, NB, Batalla, A, Bellani, M, Chye, Y, Cousijn, J, Goudriaan, AE, Hester, R, Hutchison, K, Li, C-SR, Martin-Santos, R, Momenan, R, Sinha, R, Schmaal, L, Sjoerds, Z, Solowij, N, Suo, C, van Holst, RJ, Veltman, DJ, Yücel, M, Thompson, PM, Conrod, P, Garavan, H, Brambilla, P & Lorenzetti, V 2021, 'Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group', NeuroImage: Clinical, vol. 30, 102636. https://doi.org/10.1016/j.nicl.2021.102636

TY - JOUR

T1 - Gender-related neuroanatomical differences in alcohol dependence

T2 - Findings from the ENIGMA Addiction Working Group

AU - Rossetti, Maria Gloria

AU - Patalay, Praveetha

AU - Mackey, Scott

AU - Allen, Nicholas B

AU - Batalla, Albert

AU - Bellani, Marcella

AU - Chye, Yann

AU - Cousijn, Janna

AU - Goudriaan, Anna E

AU - Hester, Robert

AU - Hutchison, Kent

AU - Li, Chiang-Shan R

AU - Martin-Santos, Rocio

AU - Momenan, Reza

AU - Sinha, Rajita

AU - Schmaal, Lianne

AU - Sjoerds, Zsuzsika

AU - Solowij, Nadia

AU - Suo, Chao

AU - van Holst, Ruth J

AU - Veltman, Dick J

AU - Yücel, Murat

AU - Thompson, Paul M

AU - Conrod, Patricia

AU - Garavan, Hugh

AU - Brambilla, Paolo

AU - Lorenzetti, Valentina

N1 - Funding Information: Data collection: Drs. Sjoerds and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Sinha received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Yücel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. Dr Lorenzetti was supported by The Australian Catholic University through a competitive scheme. Funding Information: P.T. received partial grant support from Biogen, Inc. (Boston, USA) for research unrelated to this manuscript. M.Y. has received funding from several law firms in relation to expert witness reports. Publisher Copyright: © 2021

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.

AB - Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.

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DO - 10.1016/j.nicl.2021.102636

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JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

M1 - 102636

ER -

Gender-related neuroanatomical differences in alcohol dependence: Findings from the ENIGMA Addiction Working Group

Abstract

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