Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View

Bas W.A. Peeters, Alexandra C.A. Piët, Maarten Fornerod*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
20 Downloads (Pure)

Abstract

In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells. The double membrane of the NE is perforated by nuclear pores lined with large multi-protein structures, called nuclear-pore complexes (NPCs), which selectively allow the bi-directional transport of ions and macromolecular cargo. In order to nucleate a pore, the inner and outer nuclear membrane have to fuse at the site of NPC insertion, a process requiring both lipid bilayers to be deformed into highly curved structures. How this curvature is achieved and which factors are involved in inducing and stabilizing membrane curvature at the nuclear pore remain largely unclear. In this review, we will summarize the molecular mechanisms thought to be involved in membrane curvature generation, with a particular emphasis on the role of lipids and lipid metabolism in shaping the nuclear pore membrane.

Original languageEnglish
Article number469
JournalCells
Volume11
Issue number3
DOIs
Publication statusPublished - 29 Jan 2022

Bibliographical note

Funding Information:
Funding: This research was funded by Netherlands Organisation for Health Research and Development (ZonMW), grant number 91217045.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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