Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus

Mengshi Li; Jinghua Cao; Yajun He; Zijun Zhou; Xiaodong He; Qian-Qian Zhang; Li-Jing Wang; Cui-Ling Qi

doi:10.1002/ar.23945

Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus

Mengshi Li, Jinghua Cao, Yajun He, Zijun Zhou, Xiaodong He, Qian-Qian Zhang, Li-Jing Wang, Cui-Ling Qi

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV-PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV-PyMT mice without diabetes, MMTV-PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV-PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269-277, 2019. © 2018 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	269-277
Number of pages	9
Journal	Anatomical Record
Volume	302
Issue number	2
DOIs	https://doi.org/10.1002/ar.23945
Publication status	Published - Feb 2019
Externally published	Yes

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title = "Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus",

abstract = "Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV-PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV-PyMT mice without diabetes, MMTV-PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV-PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269-277, 2019. {\textcopyright} 2018 Wiley Periodicals, Inc.",

author = "Mengshi Li and Jinghua Cao and Yajun He and Zijun Zhou and Xiaodong He and Qian-Qian Zhang and Li-Jing Wang and Cui-Ling Qi",

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doi = "10.1002/ar.23945",

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T1 - Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus

AU - Li, Mengshi

AU - Cao, Jinghua

AU - He, Yajun

AU - Zhou, Zijun

AU - He, Xiaodong

AU - Zhang, Qian-Qian

AU - Wang, Li-Jing

AU - Qi, Cui-Ling

PY - 2019/2

Y1 - 2019/2

N2 - Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV-PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV-PyMT mice without diabetes, MMTV-PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV-PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269-277, 2019. © 2018 Wiley Periodicals, Inc.

AB - Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV-PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV-PyMT mice without diabetes, MMTV-PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV-PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269-277, 2019. © 2018 Wiley Periodicals, Inc.

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JF - Anatomical Record

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ER -

Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus

Abstract

Bibliographical note

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