Genes controlling nucleotide excision repair in eukaryotic cells

Geert Weeda*, Jan H.J. Hoeijmakers, Dirk Bootsma

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

52 Citations (Scopus)

Abstract

The maintenance of genetic integrity is of vital importance to all living organisms. However, DNA – the carrier of genetic information – is continuously subject to damage induced by numerous agents from the environment and endogenous cellular metabolites. To prevent the deleterious consequences of DNA injury, an intricate network of repair systems has evolved. The biological impact of these repair mechanisms is illustrated by a number of genetic diseases that are characterized by a defect in one of the repair machineries and in general predispose individuals to cancer. This article intends to review our current understanding of the complex nucleotide excision repair pathway, a universal repair system with a broad lesion specificity. Emphasis will be on the recent advances in the genetic analysis of this process in mammalian cells.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalBioEssays
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1993

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