Abstract
In this thesis I investigated the association of genetic variants and metabolites in blood with aging and age-related outcomes by making use of a multi-omics approach and data from cohort studies across the world.
The studies included in this thesis resulted in the identification of promising genetic variants, genes, and metabolites associated with age-related outcomes such as telomere length, depression, sleep latency and sleep apnea.
The findings of this thesis contribute to a better understanding of the molecular mechanisms involved in age-related outcomes. The presented findings will provide targets for earlier diagnosis, new treatments and new prevention strategies for age-related diseases to improve healthy aging.
The studies included in this thesis resulted in the identification of promising genetic variants, genes, and metabolites associated with age-related outcomes such as telomere length, depression, sleep latency and sleep apnea.
The findings of this thesis contribute to a better understanding of the molecular mechanisms involved in age-related outcomes. The presented findings will provide targets for earlier diagnosis, new treatments and new prevention strategies for age-related diseases to improve healthy aging.
| Original language | English |
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| Award date | 29 Nov 2021 |
| Place of Publication | Rotterdam |
| Print ISBNs | 978-94-6423-430-5 |
| Publication status | Published - 29 Oct 2021 |