Genetic and metabolic studies: of aging, depression and sleep in the general population

Ashley van der Spek

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

In this thesis I investigated the association of genetic variants and metabolites in blood with aging and age-related outcomes by making use of a multi-omics approach and data from cohort studies across the world.

The studies included in this thesis resulted in the identification of promising genetic variants, genes, and metabolites associated with age-related outcomes such as telomere length, depression, sleep latency and sleep apnea.

The findings of this thesis contribute to a better understanding of the molecular mechanisms involved in age-related outcomes. The presented findings will provide targets for earlier diagnosis, new treatments and new prevention strategies for age-related diseases to improve healthy aging.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • van Duijn, Cornelia, Supervisor
  • Amin, Najaf, Co-supervisor
Award date29 Nov 2021
Place of PublicationRotterdam
Print ISBNs978-94-6423-430-5
Publication statusPublished - 29 Oct 2021

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