Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data

MH Siddiqi, T Akhtar, A Rakha, G Abbas, A Ali, N Haider, S Hayat, S Masooma, J Ahmad, MA Tariq, Mannis Oven, FM Khan

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)


To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n = 96; females, n = 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)134-139
Number of pages6
JournalLegal Medicine
Issue number2
Publication statusPublished - 2015

Cite this