Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data

MH Siddiqi; T Akhtar; A Rakha; G Abbas; A Ali; N Haider; S Hayat; S Masooma; J Ahmad; MA Tariq; Mannis Oven; FM Khan

doi:10.1016/j.legalmed.2014.09.007

Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data

MH Siddiqi, T Akhtar, A Rakha, G Abbas, A Ali, N Haider, S Hayat, S Masooma, J Ahmad, MA Tariq, Mannis Oven, FM Khan

Genetic Identification

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n = 96; females, n = 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	134-139
Number of pages	6
Journal	Legal Medicine
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.legalmed.2014.09.007
Publication status	Published - 2015

Research programs

EMC MGC-02-26-01

Access to Document

10.1016/j.legalmed.2014.09.007

http://hdl.handle.net/1765/91605

Cite this

@article{dc3666186f4441f1a454baeebaad36ea,

title = "Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data",

abstract = "To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n = 96; females, n = 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.",

author = "MH Siddiqi and T Akhtar and A Rakha and G Abbas and A Ali and N Haider and S Hayat and S Masooma and J Ahmad and MA Tariq and Mannis Oven and FM Khan",

year = "2015",

doi = "10.1016/j.legalmed.2014.09.007",

language = "Undefined/Unknown",

volume = "17",

pages = "134--139",

journal = "Legal Medicine",

issn = "1344-6223",

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TY - JOUR

T1 - Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data

AU - Siddiqi, MH

AU - Akhtar, T

AU - Rakha, A

AU - Abbas, G

AU - Ali, A

AU - Haider, N

AU - Hayat, S

AU - Masooma, S

AU - Ahmad, J

AU - Tariq, MA

AU - Oven, Mannis

AU - Khan, FM

PY - 2015

Y1 - 2015

N2 - To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n = 96; females, n = 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

AB - To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n = 96; females, n = 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.legalmed.2014.09.007

DO - 10.1016/j.legalmed.2014.09.007

M3 - Article

C2 - 25454536

SN - 1344-6223

VL - 17

SP - 134

EP - 139

JO - Legal Medicine

JF - Legal Medicine

IS - 2

ER -