Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles

JM Gregson; DF Freitag; P Surendran; NO Stitziel; R Chowdhury; S Burgess; S Kaptoge; P Gao; JR Staley; P Willeit; SF Nielsen; M Caslake; S Trompet; L M Polfus; K Kuulasmaa; J Kontto; M Perola; S Blankenberg; G Veronesi; F Gianfagna; S Mannisto; A Kimura; HH Lin; D F Reilly; M Gorski; V Mijatovic; PB Munroe; GB Ehret; A Thompson; M Uria-Nickelsen; A Malarstig; Abbas Dehghan; TF Vogt; T Sasaoka; F Takeuchi; N Kato; Y Yamada; F Kee; M Muller-Nurasyid; J Ferrieres; D Arveiler; P Amouyel; V Salomaa; E Boerwinkle; SG Thompson; I Ford; JW Jukema; N Sattar; CJ Packard; AA Majumder; DS Alam; P Deloukas; H Schunkert; NJ Samani; S Kathiresan; BG Nordestgaard; D Saleheen; JMM Howson; E Di Angelantonio; AS Butterworth; J Danesh

doi:10.1177/2047487316682186

Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles

JM Gregson, DF Freitag, P Surendran, NO Stitziel, R Chowdhury, S Burgess, S Kaptoge, P Gao, JR Staley, P Willeit, SF Nielsen, M Caslake, S Trompet, L M Polfus, K Kuulasmaa, J Kontto, M Perola, S Blankenberg, G Veronesi, F GianfagnaS Mannisto, A Kimura, HH Lin, D F Reilly, M Gorski, V Mijatovic, PB Munroe, GB Ehret, A Thompson, M Uria-Nickelsen, A Malarstig, Abbas Dehghan, TF Vogt, T Sasaoka, F Takeuchi, N Kato, Y Yamada, F Kee, M Muller-Nurasyid, J Ferrieres, D Arveiler, P Amouyel, V Salomaa, E Boerwinkle, SG Thompson, I Ford, JW Jukema, N Sattar, CJ Packard, AA Majumder, DS Alam, P Deloukas, H Schunkert, NJ Samani, S Kathiresan, BG Nordestgaard, D Saleheen, JMM Howson, E Di Angelantonio, AS Butterworth, J Danesh

Epidemiology

Research output: Contribution to journal › Article › Academic

31 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	492-504
Number of pages	13
Journal	European Journal of Preventive Cardiology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1177/2047487316682186
Publication status	Published - 2017

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EMC OR-01

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10.1177/2047487316682186

http://hdl.handle.net/1765/98411

Cite this

Gregson, JM., Freitag, DF., Surendran, P., Stitziel, NO., Chowdhury, R., Burgess, S., Kaptoge, S., Gao, P., Staley, JR., Willeit, P., Nielsen, SF., Caslake, M., Trompet, S., Polfus, L. M., Kuulasmaa, K., Kontto, J., Perola, M., Blankenberg, S., Veronesi, G., ... Danesh, J. (2017). Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles. European Journal of Preventive Cardiology, 24(5), 492-504. https://doi.org/10.1177/2047487316682186

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title = "Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles",

author = "JM Gregson and DF Freitag and P Surendran and NO Stitziel and R Chowdhury and S Burgess and S Kaptoge and P Gao and JR Staley and P Willeit and SF Nielsen and M Caslake and S Trompet and Polfus, {L M} and K Kuulasmaa and J Kontto and M Perola and S Blankenberg and G Veronesi and F Gianfagna and S Mannisto and A Kimura and HH Lin and Reilly, {D F} and M Gorski and V Mijatovic and PB Munroe and GB Ehret and A Thompson and M Uria-Nickelsen and A Malarstig and Abbas Dehghan and TF Vogt and T Sasaoka and F Takeuchi and N Kato and Y Yamada and F Kee and M Muller-Nurasyid and J Ferrieres and D Arveiler and P Amouyel and V Salomaa and E Boerwinkle and SG Thompson and I Ford and JW Jukema and N Sattar and CJ Packard and AA Majumder and DS Alam and P Deloukas and H Schunkert and NJ Samani and S Kathiresan and BG Nordestgaard and D Saleheen and JMM Howson and {Di Angelantonio}, E and AS Butterworth and J Danesh",

year = "2017",

doi = "10.1177/2047487316682186",

language = "Undefined/Unknown",

volume = "24",

pages = "492--504",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "Oxford University Press",

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Gregson, JM, Freitag, DF, Surendran, P, Stitziel, NO, Chowdhury, R, Burgess, S, Kaptoge, S, Gao, P, Staley, JR, Willeit, P, Nielsen, SF, Caslake, M, Trompet, S, Polfus, LM, Kuulasmaa, K, Kontto, J, Perola, M, Blankenberg, S, Veronesi, G, Gianfagna, F, Mannisto, S, Kimura, A, Lin, HH, Reilly, DF, Gorski, M, Mijatovic, V, Munroe, PB, Ehret, GB, Thompson, A, Uria-Nickelsen, M, Malarstig, A, Dehghan, A, Vogt, TF, Sasaoka, T, Takeuchi, F, Kato, N, Yamada, Y, Kee, F, Muller-Nurasyid, M, Ferrieres, J, Arveiler, D, Amouyel, P, Salomaa, V, Boerwinkle, E, Thompson, SG, Ford, I, Jukema, JW, Sattar, N, Packard, CJ, Majumder, AA, Alam, DS, Deloukas, P, Schunkert, H, Samani, NJ, Kathiresan, S, Nordestgaard, BG, Saleheen, D, Howson, JMM, Di Angelantonio, E, Butterworth, AS & Danesh, J 2017, 'Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles', European Journal of Preventive Cardiology, vol. 24, no. 5, pp. 492-504. https://doi.org/10.1177/2047487316682186

TY - JOUR

T1 - Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles

AU - Gregson, JM

AU - Freitag, DF

AU - Surendran, P

AU - Stitziel, NO

AU - Chowdhury, R

AU - Burgess, S

AU - Kaptoge, S

AU - Gao, P

AU - Staley, JR

AU - Willeit, P

AU - Nielsen, SF

AU - Caslake, M

AU - Trompet, S

AU - Polfus, L M

AU - Kuulasmaa, K

AU - Kontto, J

AU - Perola, M

AU - Blankenberg, S

AU - Veronesi, G

AU - Gianfagna, F

AU - Mannisto, S

AU - Kimura, A

AU - Lin, HH

AU - Reilly, D F

AU - Gorski, M

AU - Mijatovic, V

AU - Munroe, PB

AU - Ehret, GB

AU - Thompson, A

AU - Uria-Nickelsen, M

AU - Malarstig, A

AU - Dehghan, Abbas

AU - Vogt, TF

AU - Sasaoka, T

AU - Takeuchi, F

AU - Kato, N

AU - Yamada, Y

AU - Kee, F

AU - Muller-Nurasyid, M

AU - Ferrieres, J

AU - Arveiler, D

AU - Amouyel, P

AU - Salomaa, V

AU - Boerwinkle, E

AU - Thompson, SG

AU - Ford, I

AU - Jukema, JW

AU - Sattar, N

AU - Packard, CJ

AU - Majumder, AA

AU - Alam, DS

AU - Deloukas, P

AU - Schunkert, H

AU - Samani, NJ

AU - Kathiresan, S

AU - Nordestgaard, BG

AU - Saleheen, D

AU - Howson, JMM

AU - Di Angelantonio, E

AU - Butterworth, AS

AU - Danesh, J

PY - 2017

Y1 - 2017

U2 - 10.1177/2047487316682186

DO - 10.1177/2047487316682186

M3 - Article

C2 - 27940953

SN - 2047-4873

VL - 24

SP - 492

EP - 504

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

IS - 5

ER -