Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes

Cynthia J. Faust, Annemieke J.M.H. Verkerk, Peter J. Wilson, C. Phillip Morris, John J. Hopwood, Ben A. Oostra, Gail E. Herman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.

Original languageEnglish
Pages (from-to)814-817
Number of pages4
JournalGenomics
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1992

Bibliographical note

Copyright © 1992 Published by Elsevier Inc.

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