Genetic organization of the c-sis transcription unit

Ans M.w. van Den Ouweland; Jan J.m. van Groningen; Jack A. Schalken; Han W. van Neck; Henri P.J. Bloemers; Wim J.m. van de Ven

doi:10.1093/nar/15.3.959

Genetic organization of the c-sis transcription unit

Ans M.w. van Den Ouweland, Jan J.m. van Groningen, Jack A. Schalken, Han W. van Neck, Henri P.J. Bloemers, Wim J.m. van de Ven

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found In the deduced translational product of feline c-sis and It was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5′ end of exon 7 of human c-sis but absent In the simian sarcoma virus v-sis oncogene was also present In the feline c-sis proto-oncogene.

Original language	English
Pages (from-to)	959-970
Number of pages	12
Journal	Nucleic Acids Research
Volume	15
Issue number	3
DOIs	https://doi.org/10.1093/nar/15.3.959
Publication status	Published - 11 Feb 1987

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS We thank Adrie van Bokhoven, Inge van Renesse, Peter Hendriksen and Saskya Ebeling for their excellent technical assistance. This work was supported by the Netherlands Cancer Foundation, Contract No. NUKC Bioch. 85~9.

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10.1093/nar/15.3.959

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title = "Genetic organization of the c-sis transcription unit",

abstract = "The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found In the deduced translational product of feline c-sis and It was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5′ end of exon 7 of human c-sis but absent In the simian sarcoma virus v-sis oncogene was also present In the feline c-sis proto-oncogene.",

author = "{van Den Ouweland}, {Ans M.w.} and {van Groningen}, {Jan J.m.} and Schalken, {Jack A.} and {van Neck}, {Han W.} and Bloemers, {Henri P.J.} and {van de Ven}, {Wim J.m.}",

note = "Funding Information: ACKNOWLEDGEMENTS We thank Adrie van Bokhoven, Inge van Renesse, Peter Hendriksen and Saskya Ebeling for their excellent technical assistance. This work was supported by the Netherlands Cancer Foundation, Contract No. NUKC Bioch. 85~9.",

year = "1987",

month = feb,

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doi = "10.1093/nar/15.3.959",

language = "English",

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journal = "Nucleic Acids Research",

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T1 - Genetic organization of the c-sis transcription unit

AU - van Den Ouweland, Ans M.w.

AU - van Groningen, Jan J.m.

AU - Schalken, Jack A.

AU - van Neck, Han W.

AU - Bloemers, Henri P.J.

AU - van de Ven, Wim J.m.

N1 - Funding Information: ACKNOWLEDGEMENTS We thank Adrie van Bokhoven, Inge van Renesse, Peter Hendriksen and Saskya Ebeling for their excellent technical assistance. This work was supported by the Netherlands Cancer Foundation, Contract No. NUKC Bioch. 85~9.

PY - 1987/2/11

Y1 - 1987/2/11

N2 - The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found In the deduced translational product of feline c-sis and It was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5′ end of exon 7 of human c-sis but absent In the simian sarcoma virus v-sis oncogene was also present In the feline c-sis proto-oncogene.

AB - The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found In the deduced translational product of feline c-sis and It was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5′ end of exon 7 of human c-sis but absent In the simian sarcoma virus v-sis oncogene was also present In the feline c-sis proto-oncogene.

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U2 - 10.1093/nar/15.3.959

DO - 10.1093/nar/15.3.959

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SN - 0305-1048

VL - 15

SP - 959

EP - 970

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 3

ER -

Genetic organization of the c-sis transcription unit

Abstract

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