Genetic variants of FOXP3 influence graft survival in kidney transplant patients

Anja U. Engela; Karin Boer; Joke I. Roodnat; Annemiek M.A. Peeters; Paul H. Eilers; Judith A. Kal-van Gestel; Fernando Rivadeneira; Willem Weimar; Carla C. Baan

doi:10.1016/j.humimm.2013.02.008

Genetic variants of FOXP3 influence graft survival in kidney transplant patients

Anja U. Engela^*
, Karin Boer
, Joke I. Roodnat
, Annemiek M.A. Peeters
, Paul H. Eilers
, Judith A. Kal-van Gestel
, Fernando Rivadeneira
, Willem Weimar
, Carla C. Baan

^*Corresponding author for this work

Erasmus University Rotterdam

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

FOXP3⁺ regulatory T cells (T_reg) play a role in controlling alloreactivity. It has been shown that short (GT)_n dinucleotide repeats ((GT)₁₅; S) in the promoter region of the FOXP3 gene enhance the promoter activity when compared to long (GT)_n repeats ((GT)₁₆; L). The present study retrospectively investigated the influence of this (GT)_n FOXP3 gene polymorphism on renal allograft survival. A total of 599 consecutive first-time kidney transplant patients (median follow-up time 7.7years) were subdivided according to their FOXP3 genotype into the S-genotype group (SG) and the L-genotype group (LG). The SG was superior to the LG in both general graft survival censored for death (logrank test, p=0.013) and graft survival following acute rejection (p=0.021). Multivariate analysis defined the (GT)_n FOXP3 dinucleotide repeat polymorphism as an independent factor and confirmed an advantage for the SG in renal allograft survival (HR=0.67, 95% CI 0.48-0.94, p=0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients.

Original language	English
Pages (from-to)	751-757
Number of pages	7
Journal	Human Immunology
Volume	74
Issue number	6
DOIs	https://doi.org/10.1016/j.humimm.2013.02.008
Publication status	Published - Jun 2013

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EMC MM-04-39-05
EMC NIHES-01-66-01

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10.1016/j.humimm.2013.02.008

http://hdl.handle.net/1765/39695

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title = "Genetic variants of FOXP3 influence graft survival in kidney transplant patients",

abstract = "FOXP3+ regulatory T cells (Treg) play a role in controlling alloreactivity. It has been shown that short (GT)n dinucleotide repeats ((GT)15; S) in the promoter region of the FOXP3 gene enhance the promoter activity when compared to long (GT)n repeats ((GT)16; L). The present study retrospectively investigated the influence of this (GT)n FOXP3 gene polymorphism on renal allograft survival. A total of 599 consecutive first-time kidney transplant patients (median follow-up time 7.7years) were subdivided according to their FOXP3 genotype into the S-genotype group (SG) and the L-genotype group (LG). The SG was superior to the LG in both general graft survival censored for death (logrank test, p=0.013) and graft survival following acute rejection (p=0.021). Multivariate analysis defined the (GT)n FOXP3 dinucleotide repeat polymorphism as an independent factor and confirmed an advantage for the SG in renal allograft survival (HR=0.67, 95\% CI 0.48-0.94, p=0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients.",

author = "Engela, \{Anja U.\} and Karin Boer and Roodnat, \{Joke I.\} and Peeters, \{Annemiek M.A.\} and Eilers, \{Paul H.\} and \{Kal-van Gestel\}, \{Judith A.\} and Fernando Rivadeneira and Willem Weimar and Baan, \{Carla C.\}",

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AU - Engela, Anja U.

AU - Boer, Karin

AU - Roodnat, Joke I.

AU - Peeters, Annemiek M.A.

AU - Eilers, Paul H.

AU - Kal-van Gestel, Judith A.

AU - Rivadeneira, Fernando

AU - Weimar, Willem

AU - Baan, Carla C.

PY - 2013/6

Y1 - 2013/6

N2 - FOXP3+ regulatory T cells (Treg) play a role in controlling alloreactivity. It has been shown that short (GT)n dinucleotide repeats ((GT)15; S) in the promoter region of the FOXP3 gene enhance the promoter activity when compared to long (GT)n repeats ((GT)16; L). The present study retrospectively investigated the influence of this (GT)n FOXP3 gene polymorphism on renal allograft survival. A total of 599 consecutive first-time kidney transplant patients (median follow-up time 7.7years) were subdivided according to their FOXP3 genotype into the S-genotype group (SG) and the L-genotype group (LG). The SG was superior to the LG in both general graft survival censored for death (logrank test, p=0.013) and graft survival following acute rejection (p=0.021). Multivariate analysis defined the (GT)n FOXP3 dinucleotide repeat polymorphism as an independent factor and confirmed an advantage for the SG in renal allograft survival (HR=0.67, 95% CI 0.48-0.94, p=0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients.

AB - FOXP3+ regulatory T cells (Treg) play a role in controlling alloreactivity. It has been shown that short (GT)n dinucleotide repeats ((GT)15; S) in the promoter region of the FOXP3 gene enhance the promoter activity when compared to long (GT)n repeats ((GT)16; L). The present study retrospectively investigated the influence of this (GT)n FOXP3 gene polymorphism on renal allograft survival. A total of 599 consecutive first-time kidney transplant patients (median follow-up time 7.7years) were subdivided according to their FOXP3 genotype into the S-genotype group (SG) and the L-genotype group (LG). The SG was superior to the LG in both general graft survival censored for death (logrank test, p=0.013) and graft survival following acute rejection (p=0.021). Multivariate analysis defined the (GT)n FOXP3 dinucleotide repeat polymorphism as an independent factor and confirmed an advantage for the SG in renal allograft survival (HR=0.67, 95% CI 0.48-0.94, p=0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients.

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DO - 10.1016/j.humimm.2013.02.008

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JO - Human Immunology

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ER -

Genetic variants of FOXP3 influence graft survival in kidney transplant patients

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